Haplotype analysis of the Mexican frameshift Cd 11(-T) and -28A->C beta-thalassemia alleles

The origins of the -28 A-->C and frameshift Cd 11-T(Fs Cd 11 -T) alleles were investigated by beta-globin duster haplotype analysis. These alleles were found in a Mexican mestizo family with beta-thalassemia (beta-thal). The -28 A-->C mutation was described previously in Kurdish Jews linked to the most common haplotype in the world (+----++), the same haplotype observed in this Mexican family. Therefore, it is not possible to assess a new origin of the -28 A-->C mutation in our population. The Fs Cd 11 -T allele, not reported to date in any other populations, was linked to the -++--+- haplotype (sixth in frequency in the world). This haplotype has not been reported in association with any beta-thal mutant, suggesting a Mexican origin for the Cd 11 -T mutation. (C) 1996 Wiley-Liss, Inc.