T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019

被引：134

作者：

Jiang, Mei ^{[1
]}

Guo, Yang ^{[1
]}

Luo, Qing ^{[1
]}

Huang, ZiKun ^{[1
]}

Zhao, Rui ^{[1
]}

Liu, ShuYuan ^{[1
]}

Le, AiPing ^{[2
]}

Li, JunMing ^{[1
]}

Wan, LaGen ^{[1
]}

机构：

[1] Nanchang Univ, Dept Clin Lab, Affiliated Hosp 1, 17 Yongwai Zheng Jie, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Dept Transfus, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 02期

关键词：

SARS-CoV2; lymphocyte subsets; diagnosis; prognosis;

D O I：

10.1093/infdis/jiaa252

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4(+) T cells but a severe decrease in CD8(+) T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8(+ )T and CD4(+)T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.

引用

页码：198 / 202

页数：5

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