Solvent-Free Synthesis of Hydrazine-Substituted Enaminones via a One-Pot Four-Component Reaction

被引：7
作者：
Alizadeh, Abdolali [1 ]
Babaki, Mohadeseh [1 ]
Zohreh, Nasrin [1 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem, Tehran 18716, Iran
来源：
SYNTHESIS-STUTTGART | 2008年 / 20期
关键词：
diketene; diisopropyl diazodicarboxylate; four-component reaction; solvent-free reaction; hydrazine; enamine; enaminone;
D O I：
10.1055/s-0028-1083142
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A four-component reaction for the synthesis of hydrazine-substituted enaminones is illustrated. In situ generation of a beta-keto ester or beta-keto amide from diketene and ROH or RNH(2) and then reaction with a primary amine to produce enaminones, followed by functionalization of the adduct by C-N bond formation through reaction with diisopropyl diazodicarboxylate, are performed under solvent-free conditions in one pot to obtain the title compound in good yield.
引用
收藏
页码：3295 / 3298
页数：4
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