microRNAs in nociceptive circuits as predictors of future clinical applications

被引：64

作者：

Kress, Michaela ^{[1
]}

Huettenhofer, Alexander ^{[2
]}

Landry, Marc ^{[3
]}

Kuner, Rohini ^{[4
]}

Favereaux, Alexandre ^{[3
]}

Greenberg, David ^{[5
]}

Bednarik, Josef ^{[6
]}

Heppenstall, Paul ^{[7
]}

Kronenberg, Florian ^{[2
]}

Malcangio, Marzia ^{[8
]}

Rittner, Heike ^{[9
]}

Ueceyler, Nurcan ^{[9
]}

Trajanoski, Zlatko ^{[2
]}

Mouritzen, Peter ^{[10
]}

Birklein, Frank ^{[11
]}

Sommer, Claudia ^{[9
]}

Soreq, Hermona ^{[12
]}

机构：

[1] Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, A-6020 Innsbruck, Austria

[3] Univ Bordeaux, CNRS, Interdisciplinary Inst Neurosci, UMR 5297, Bordeaux, France

[4] Heidelberg Univ, Heidelberg, Germany

[5] Hebrew Univ Jerusalem, Jerusalem, Israel

[6] Univ Hosp Brno, Brno, Czech Republic

[7] European Mol Biol Lab, Monterotondo, Italy

[8] Kings Coll London, London WC2R 2LS, England

[9] Univ Hosp Wurzburg, Wurzburg, Germany

[10] Exiqon AS, Vedbaek, Denmark

[11] Univ Hosp Mainz, Mainz, Germany

[12] Hebrew Univ Jerusalem, Dept Biol Chem, Lab Mol Neurosci, Jerusalem, Israel

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2013年 / 6卷

关键词：

chronic pain; biomarker; polymotphism; miRNA-based diagnostics; miRNA expression patterns; miRNA polymotphisms; antagomir; miRNA-based analgesic; REGIONAL PAIN SYNDROME; CHRONIC CONSTRICTION INJURY; PERIPHERAL-NERVE INJURY; NEUROPATHIC PAIN; SPINAL-CORD; SMALL RNAS; LONG-TERM; DIFFERENTIAL EXPRESSION; CIRCULATING MICRORNAS; THERAPEUTIC TARGETS;

D O I：

10.3389/fnmol.2013.00033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs and microRNAs (miRNAs) in particular regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. Furthermore, predisposing miRNA expression patterns and interindividual variations and polymorphisms in miRNAs and/or their binding sites may serve as biomarkers for pain and help to predict individual risks for certain types of pain and responsiveness to analgesic drugs. miRNA-based diagnostics are expected to develop into hands-on tools that allow better patient stratification, improved mechanism-based treatment, and targeted prevention strategies for high risk individuals.

引用

页数：11

共 146 条

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