Catalytic asymmetric Mukaiyama aldol reactions in aqueous media

被引：110

作者：

Kobayashi, S ^{[1
]}

Nagayama, S ^{[1
]}

Busujima, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(99)00440-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral copper(II)-catalyzed asymmetric aldol reactions of silyl enol ethers with aldehydes (the Mukaiyama aldol reaction) have been performed in an ethanol-water solution. The use of the protic solvent including water is a key to achieve these reactions. Moreover, a catalytic asymmetric aldol reaction in pure water without using organic solvents has also been successfully carried out. This report has proposed and demonstrated a new concept for solvents in catalytic asymmetric aldol reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8739 / 8746

页数：8

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