Circulating microRNAs in cellular and antibody- mediated heart transplant rejection

被引：17

作者：

Shah, Palak ^{[1
,2
]}

Agbor-Enoh, Sean ^{[2
,3
,4
]}

Bagchi, Pramita ^{[5
]}

deFilippi, Christopher R. ^{[6
]}

Mercado, Angela ^{[1
]}

Diao, Gouqing ^{[7
]}

Morales, Dave J. P. ^{[8
]}

Shah, Keyur B. ^{[9
]}

Najjar, Samer S. ^{[10
]}

Feller, Erika ^{[11
]}

Hsu, Steven ^{[3
]}

Rodrigo, Maria E. ^{[9
]}

Lewsey, Sabra C. ^{[3
]}

Jang, Moon Kyoo ^{[2
,4
]}

Marboe, Charles ^{[12
]}

Berry, Gerald J. ^{[13
]}

Khush, Kiran K. ^{[13
]}

Valantine, Hannah A. ^{[13
]}

Investigators, GRAfT

机构：

[1] Inova Heart & Vasc Inst, Heart Failure, Mech Circulatory Support & Transplant, Falls Church, VA USA

[2] Genom Res Alliance Transplantat GRAfT, Bethesda, MD USA

[3] Johns Hopkins Sch Med, Dept Med, Baltimore, MD USA

[4] Natl Heart Lung & Blood Inst, Appl Precis Genom, Bethesda, MD USA

[5] George Mason Univ, Volgenau Sch Engn, Fairfax, VA USA

[6] Inova Heart & Vasc Inst, Cardiovasc Med, Falls Church, VA USA

[7] George Washington Univ, Milken Inst Sch Publ Hlth, Washington, DC USA

[8] Stanford Univ, Heart Failure & Transplantat, Palo Alto, CA USA

[9] Virginia Commonwealth Univ, Pauley Heart Ctr, Richmond, VA USA

[10] Washington Hosp Ctr, Medstar Heart & Vasc Inst, Adv Heart Failure Program, Washington, DC USA

[11] Univ Maryland, Heart Failure & Transplantat, Baltimore, MD USA

[12] New York Presbyterian Univ, Hosp Cornell & Columbia, Dept Pathol, New York, NY USA

[13] Stanford Univ, Sch Med, Palo Alto, CA USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2022年 / 41卷 / 10期

关键词：

microRNA; heart transplantation; allograft rejection; biomarker; INTERNATIONAL SOCIETY; WORKING FORMULATION; ETHNIC DISPARITIES; RACIAL-DIFFERENCES; EXPRESSION; DIAGNOSIS; BIOMARKERS; STANDARDIZATION; NOMENCLATURE; OUTCOMES;

D O I：

10.1016/j.healun.2022.06.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Noninvasive monitoring of heart allograft health is important to improve clinical out-comes. MicroRNAs (miRs) are promising biomarkers of cardiovascular disease and limited studies suggest they can be used to noninvasively diagnose acute heart transplant rejection. METHODS: The Genomic Research Alliance for Transplantation (GRAfT) is a multicenter prospective cohort study that phenotyped heart transplant patients from 5 mid-Atlantic centers. Patients who had no history of rejection after transplant were compared to patients with acute cellular rejection (ACR) or antibody-mediated rejection (AMR). Small RNA sequencing was performed on plasma samples col-lected at the time of an endomyocardial biopsy. Differential miR expression was performed with adjustment for clinical covariates. Regression was used to develop miR panels with high diagnostic accuracy for ACR and AMR. These panels were then validated in independent samples from GRAfT and Stanford University. Receiver operating characteristic curves were generated and area under the curve (AUC) statistics calculated. Distinct ACR and AMR clinical scores were developed to translate miR expression data for clinical use.

引用

页码：1401 / 1413

页数：13

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