The gut microbiota: a key regulator of metabolic diseases

被引：39

作者：

Yang, Jin-Young ^{[1
]}

Kweon, Mi-Na ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Convergence Med,Mucosal Immunol Lab, Seoul 05505, South Korea

来源：

BMB REPORTS | 2016年 / 49卷 / 10期

关键词：

Gut microbiota; Metabolic disorder; Obesity; Short-chain fatty acids; Type; 2; diabetes; PROTEIN-COUPLED RECEPTOR; BILE-ACID METABOLISM; IMMUNE-SYSTEM; T-CELLS; OBESITY; DIET; INFLAMMATION; BUTYRATE; WEIGHT; FAT;

D O I：

10.5483/BMBRep.2016.49.10.144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prevalence of obesity and type 2 diabetes, two closely linked metabolic disorders, is increasing worldwide. Over the past decade, the connection between these disorders and the microbiota of the gut has become a major focus of biomedical research, with recent studies demonstrating the fundamental role of intestinal microbiota in the regulation and pathogenesis of metabolic disorders. Because of the complexity of the microbiota community, however, the underlying molecular mechanisms by which the gut microbiota is associated with metabolic disorders remain poorly understood. In this review, we summarize recent studies that investigate the role of the microbiota in both human subjects and animal models of disease and discuss relevant therapeutic targets for future research.

引用

页码：536 / 541

页数：6

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