Paths to stemness: building the ultimate antitumour T cell

被引：477

作者：

Gattinoni, Luca ^{[1
]}

Klebanoff, Christopher A. ^{[1
]}

Restifo, Nicholas P. ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 10期

基金：

美国国家卫生研究院;

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; BETA-CATENIN; SELF-RENEWAL; CENTRAL MEMORY; CUTTING EDGE; LONG-TERM; EFFECTOR DIFFERENTIATION; TRANSCRIPTION FACTORS; DIRECT CONVERSION; ADOPTIVE TRANSFER;

D O I：

10.1038/nrc3322

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stem cells are defined by the ability to self-renew and to generate differentiated progeny, qualities that are maintained by evolutionarily conserved pathways that can lead to cancer when deregulated. There is now evidence that these stem cell-like attributes and signalling pathways are also shared among subsets of mature memory T lymphocytes. We discuss how using stem cell-like T cells can overcome the limitations of current adoptive T cell therapies, including inefficient T cell engraftment, persistence and ability to mediate prolonged immune attack. Conferring stemness to antitumour T cells might unleash the full potential of cellular therapies.

引用

页码：671 / 684

页数：14

共 197 条

[81] GRAFT-VERSUS-LEUKEMIA EFFECT OF DONOR LYMPHOCYTE TRANSFUSIONS IN MARROW GRAFTED PATIENTS [J].

KOLB, HJ ;

SCHATTENBERG, A ;

GOLDMAN, JM ;

HERTENSTEIN, B ;

JACOBSEN, N ;

ARCESE, W ;

LJUNGMAN, P ;

FERRANT, A ;

VERDONCK, L ;

NIEDERWIESER, D ;

VANRHEE, F ;

MITTERMUELLER, J ;

DEWITTE, T ;

HOLLER, E ;

ANSARI, H .

BLOOD, 1995, 86 (05) :2041-2050

[82] Human TH17 Cells Are Long-Lived Effector Memory Cells [J].

Kryczek, Ilona ;

Zhao, Ende ;

Liu, Yan ;

Wang, Yin ;

Vatan, Linhua ;

Szeliga, Wojciech ;

Moyer, Jeffrey ;

Klimczak, Aleksandra ;

Lange, Andrzej ;

Zou, Weiping .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (104)

[83] Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1+ionomycin in IL-7+IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2 [J].

Le, Hanh K. ;

Graham, Laura ;

Miller, Catriona H. T. ;

Kmieciak, Maciej ;

Manjili, Masoud H. ;

Bear, Harry Douglas .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (10) :1565-1576

[84] T lineage differentiation from induced pluripotent stem cells [J].

Lei, Fengyang ;

Haque, Rizwanul ;

Weiler, Lauren ;

Vrana, Kent E. ;

Song, Jianxun .

CELLULAR IMMUNOLOGY, 2009, 260 (01) :1-5

[85] Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation [J].

Leonard, WJ ;

Spolski, R .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (09) :688-698

[86] IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response [J].

Li, YQ ;

Bleakley, M ;

Yee, C .

JOURNAL OF IMMUNOLOGY, 2005, 175 (04) :2261-2269

[87] BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells [J].

Li, Zhongwei ;

Fei, Teng ;

Zhang, Jianping ;

Zhu, Gaoyang ;

Wang, Lu ;

Lu, Danyu ;

Chi, Xiaochun ;

Teng, Yan ;

Hou, Ning ;

Yang, Xiao ;

Zhang, Hongquan ;

Han, Jing-Dong J. ;

Chen, Ye-Guang .

CELL STEM CELL, 2012, 10 (02) :171-182

[88] The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation [J].

Lian, Ian ;

Kim, Joungmok ;

Okazawa, Hideki ;

Zhao, Jiagang ;

Zhao, Bin ;

Yu, Jindan ;

Chinnaiyan, Arul ;

Israel, Mason A. ;

Goldstein, Lawrence S. B. ;

Abujarour, Ramzey ;

Ding, Sheng ;

Guan, Kun-Liang .

GENES & DEVELOPMENT, 2010, 24 (11) :1106-1118

[89] Reprogramming of T Cells from Human Peripheral Blood [J].

Loh, Yuin-Han ;

Hartung, Odelya ;

Li, Hu ;

Guo, Chunguang ;

Sahalie, Julie M. ;

Manos, Philip D. ;

Urbach, Achia ;

Heffner, Garrett C. ;

Grskovic, Marica ;

Vigneault, Francois ;

Lensch, M. William ;

Park, In-Hyun ;

Agarwal, Suneet ;

Church, George M. ;

Collins, James J. ;

Irion, Stefan ;

Daley, George Q. .

CELL STEM CELL, 2010, 7 (01) :15-19

[90] Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma [J].

Louis, Chrystal U. ;

Savoldo, Barbara ;

Dotti, Gianpietro ;

Pule, Martin ;

Yvon, Eric ;

Myers, G. Doug ;

Rossig, Claudia ;

Russell, Heidi V. ;

Diouf, Oumar ;

Liu, Enli ;

Liu, Hao ;

Wu, Meng-Fen ;

Gee, Adrian P. ;

Mei, Zhuyong ;

Rooney, Cliona M. ;

Heslop, Helen E. ;

Brenner, Malcolm K. .

BLOOD, 2011, 118 (23) :6050-6056

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