Paths to stemness: building the ultimate antitumour T cell

被引：477

作者：

Gattinoni, Luca ^{[1
]}

Klebanoff, Christopher A. ^{[1
]}

Restifo, Nicholas P. ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 10期

基金：

美国国家卫生研究院;

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; BETA-CATENIN; SELF-RENEWAL; CENTRAL MEMORY; CUTTING EDGE; LONG-TERM; EFFECTOR DIFFERENTIATION; TRANSCRIPTION FACTORS; DIRECT CONVERSION; ADOPTIVE TRANSFER;

D O I：

10.1038/nrc3322

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stem cells are defined by the ability to self-renew and to generate differentiated progeny, qualities that are maintained by evolutionarily conserved pathways that can lead to cancer when deregulated. There is now evidence that these stem cell-like attributes and signalling pathways are also shared among subsets of mature memory T lymphocytes. We discuss how using stem cell-like T cells can overcome the limitations of current adoptive T cell therapies, including inefficient T cell engraftment, persistence and ability to mediate prolonged immune attack. Conferring stemness to antitumour T cells might unleash the full potential of cellular therapies.

引用

页码：671 / 684

页数：14

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