Multiple Distinctive Demyelinating Lesions Caused by Eosinophilic Granulomatosis With Polyangiitis: Case Report and Literature Review

被引：3

作者：

Xu, Dingkang ^{[1
]}

Xu, Hongen ^{[2
]}

Wang, Fang ^{[1
]}

Wang, Guoqing ^{[1
]}

Wei, Qingjie ^{[1
]}

Lei, Shixiong ^{[1
]}

Gao, Qiang ^{[1
]}

Zhang, Qi ^{[2
,3
]}

Guo, Fuyou ^{[1
,4
]}

机构：

[1] Zhengzhou Univ, Dept Neurosurg, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[2] Zhengzhou Univ, Ctr Precis Med, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Henan, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Key Lab Neurosurg Dis, Zhengzhou, Henan, Peoples R China

来源：

FRONTIERS IN NEUROLOGY | 2019年 / 10卷

关键词：

EGPA; DNA sequencing; HLA; SNP; CNS involvement; neurosurgery; differential diagnosis; ANCA-ASSOCIATED VASCULITIS; CHURG-STRAUSS; FOLLOW-UP; RITUXIMAB; RISK;

D O I：

10.3389/fneur.2019.00213

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare rheumatic immune disease characterized by vasculitis of small- and medium-sized blood vessels. Central nervous system (CNS) involvement frequently consists of cerebrovascular disease; a manifestation with multiple demyelinating lesions has never been reported in detail. This report describes a 38-year-old man, who presented with progressive memory deterioration and underwent microsurgery; EGPA was subsequently confirmed. Unique clinical and radiological features as well as immunohistological outcomes and DNA sequencing revealed a potential disease-associated human leukocyte antigen (HLA) type, and single-nucleotide polymorphisms (SNPs) are described for this uncommon case. Although EGPA rarely involves the CNS, this differential diagnosis should be considered when patients present with a history of nasosinusitis, elevated eosinophil percentage, clinical pulmonitis, and neurologicalmanifestations. Microsurgery is necessary for precise diagnosis and effective treatment.

引用

页数：7

共 19 条

[11] Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases [J].

Sozener, Zeynep Celebi ;

Gorgulu, Begum ;

Mungan, Dilsad ;

Sin, Betul Ayse ;

Misirligil, Zeynep ;

Aydin, Omur ;

Bavbek, Sevim .

WORLD ALLERGY ORGANIZATION JOURNAL, 2018, 11

[12] OptiType: precision HLA typing from next-generation sequencing data [J].

Szolek, Andras ;

Schubert, Benjamin ;

Mohr, Christopher ;

Sturm, Marc ;

Feldhahn, Magdalena ;

Kohlbacher, Oliver .

BIOINFORMATICS, 2014, 30 (23) :3310-3316

[13] Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases [J].

Terao, Chikashi ;

Yoshifuji, Hajime ;

Yamano, Yoshihisa ;

Kojima, Hiroto ;

Yurugi, Kimiko ;

Miura, Yasuo ;

Maekawa, Taira ;

Handa, Hiroshi ;

Ohmura, Koichiro ;

Saji, Hiroh ;

Mimori, Tsuneyo ;

Matsuda, Fumihiko .

RHEUMATOLOGY, 2016, 55 (09) :1686-1692

[14] Association of Takayasu arteritis with HLA-B☆67:01 and two amino acids in HLA-B protein [J].

Terao, Chikashi ;

Yoshifuji, Hajime ;

Ohmura, Koichiro ;

Murakami, Kosaku ;

Kawabata, Daisuke ;

Yurugi, Kimiko ;

Tazaki, Junichi ;

Kinoshita, Hideyuki ;

Kimura, Akinori ;

Akizuki, Masashi ;

Kawaguchi, Yasushi ;

Yamanaka, Hisashi ;

Miura, Yasuo ;

Maekawa, Taira ;

Saji, Hiroo ;

Mimori, Tsuneyo ;

Matsuda, Fumihiko .

RHEUMATOLOGY, 2013, 52 (10) :1769-1774

[15] Rituximab as Induction Therapy in Eosinophilic Granulomatosis with Polyangiitis Refractory to Conventional Immunosuppressive Treatment: A 36-Month Follow-Up Analysis [J].

Thiel, Jens ;

Troilo, Arianna ;

Salzer, Ulrich ;

Schleyer, Theresa ;

Halmschlag, Kirsten ;

Rizzi, Marta ;

Frede, Natalie ;

Venhoff, Ana ;

Voll, Reinhard E. ;

Venhoff, Nils .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2017, 5 (06) :1556-1563

[16] HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome [J].

Vaglio, Augusto ;

Martorana, Davide ;

Maggiore, Umberto ;

Grasselli, Chiara ;

Zanetti, Adele ;

Pesci, Alberto ;

Garini, Giovanni ;

Manganelli, Paolo ;

Bottero, Paolo ;

Tumiati, Bruno ;

Sinico, Renato A. ;

Savi, Mario ;

Buzio, Carlo ;

Neri, Tauro M. .

ARTHRITIS AND RHEUMATISM, 2007, 56 (09) :3159-3166

[17] Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis [J].

Wechsler, M. E. ;

Akuthota, P. ;

Jayne, D. ;

Khoury, P. ;

Klion, A. ;

Langford, C. A. ;

Merkel, P. A. ;

Moosig, F. ;

Specks, U. ;

Cid, M. C. ;

Luqmani, R. ;

Brown, J. ;

Mallett, S. ;

Philipson, R. ;

Yancey, S. W. ;

Steinfeld, J. ;

Weller, P. F. ;

Gleich, G. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (20) :1921-1932

[18] Fast and accurate HLA typing from short-read next-generation sequence data with xHLA [J].

Xie, Chao ;

Yeo, Zhen Xuan ;

Wong, Marie ;

Piper, Jason ;

Long, Tao ;

Kirkness, Ewen F. ;

Biggs, William H. ;

Bloom, Ken ;

Spellman, Stephen ;

Vierra-Green, Cynthia ;

Brady, Colleen ;

Scheuermann, Richard H. ;

Telenti, Amalio ;

Howard, Sally ;

Brewerton, Suzanne ;

Turpaz, Yaron ;

Venter, J. Craig .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (30) :8059-8064

[19] Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma [J].

Zhang, Chenan ;

de Smith, Adam J. ;

Smirnov, Ivan V. ;

Wiencke, John K. ;

Wiemels, Joseph L. ;

Witte, John S. ;

Walsh, Kyle M. .

JOURNAL OF NEURO-ONCOLOGY, 2017, 135 (02) :237-244

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