Multiple Distinctive Demyelinating Lesions Caused by Eosinophilic Granulomatosis With Polyangiitis: Case Report and Literature Review

被引：3

作者：

Xu, Dingkang ^{[1
]}

Xu, Hongen ^{[2
]}

Wang, Fang ^{[1
]}

Wang, Guoqing ^{[1
]}

Wei, Qingjie ^{[1
]}

Lei, Shixiong ^{[1
]}

Gao, Qiang ^{[1
]}

Zhang, Qi ^{[2
,3
]}

Guo, Fuyou ^{[1
,4
]}

机构：

[1] Zhengzhou Univ, Dept Neurosurg, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[2] Zhengzhou Univ, Ctr Precis Med, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Henan, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Key Lab Neurosurg Dis, Zhengzhou, Henan, Peoples R China

来源：

FRONTIERS IN NEUROLOGY | 2019年 / 10卷

关键词：

EGPA; DNA sequencing; HLA; SNP; CNS involvement; neurosurgery; differential diagnosis; ANCA-ASSOCIATED VASCULITIS; CHURG-STRAUSS; FOLLOW-UP; RITUXIMAB; RISK;

D O I：

10.3389/fneur.2019.00213

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare rheumatic immune disease characterized by vasculitis of small- and medium-sized blood vessels. Central nervous system (CNS) involvement frequently consists of cerebrovascular disease; a manifestation with multiple demyelinating lesions has never been reported in detail. This report describes a 38-year-old man, who presented with progressive memory deterioration and underwent microsurgery; EGPA was subsequently confirmed. Unique clinical and radiological features as well as immunohistological outcomes and DNA sequencing revealed a potential disease-associated human leukocyte antigen (HLA) type, and single-nucleotide polymorphisms (SNPs) are described for this uncommon case. Although EGPA rarely involves the CNS, this differential diagnosis should be considered when patients present with a history of nasosinusitis, elevated eosinophil percentage, clinical pulmonitis, and neurologicalmanifestations. Microsurgery is necessary for precise diagnosis and effective treatment.

引用

页数：7

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