Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy

被引：81

作者：

Qin, Xingping ^{[1
,2
]}

Cheng, Jing ^{[1
]}

Zhong, Yi ^{[1
]}

Mahgoub, Omer Kemal ^{[1
]}

Akter, Farhana ^{[2
,3
]}

Fan, Yanqin ^{[4
]}

Aldughaim, Mohammed ^{[2
]}

Xie, Qiurong ^{[5
]}

Qin, Lingxia ^{[6
]}

Gu, Lijuan ^{[4
]}

Jian, Zhihong ^{[1
]}

Xiong, Xiaoxing ^{[1
]}

Liu, Renzhong ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan, Hubei, Peoples R China

[2] Harvard Med Sch, Dept Neurosurg, Boston, MA 02115 USA

[3] Univ Cambridge, Dept Neurosci, Cambridge, England

[4] Wuhan Univ, Renmin Hosp, Cent Lab, Wuhan, Hubei, Peoples R China

[5] Wuhan Univ, Renmin Hosp, Dept Gynecol & Obstet, Wuhan, Hubei, Peoples R China

[6] Wuhan Univ, Renmin Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2019年 / 12卷

基金：

中国国家自然科学基金;

关键词：

neonatal hypoxic ischemic encephalopathy; mechanisms and therapy; reactive oxygen species; oxidative stress; clinical biomarkers; antioxidant therapy; mitochondria; NITRIC-OXIDE SYNTHASE; BRAIN-INJURY; REACTIVE OXYGEN; LIPID-PEROXIDATION; CEREBRAL-ISCHEMIA; RAT MODEL; THERAPEUTIC HYPOTHERMIA; REPERFUSION INJURY; N-ACETYLCYSTEINE; SELECTIVE HEAD;

D O I：

10.3389/fnmol.2019.00088

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hypoxic ischemic encephalopathy (HIE) is a type of neonatal brain injury, which occurs due to lack of supply and oxygen deprivation to the brain. It is associated with a high morbidity and mortality rate. There are several therapeutic strategies that can be used to improve outcomes in patients with HIE. These include cell therapies such as marrow mesenchymal stem cells (MSCs) and umbilical cord blood stem cells (UCBCs), which are being incorporated into the new protocols for the prevention of ischemic brain damage. The focus of this review is to discuss the mechanism of oxidative stress in HIE and summarize the current available treatments for HIE. We hope that a better understanding of the relationship between oxidative stress and HIE will provide new insights on the potential therapy of this devastating condition.

引用

页数：10

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