Generating, partitioning, targeting and functioning of superoxide in mitochondria

被引：181
作者：
Liu, SS
机构：
[1] State Key Lab. Biomembrane Memb. B., Institute of Zoology, Chinese Academy of Sciences, Haidian, Beijing 100080
来源：
BIOSCIENCE REPORTS | 1997年 / 17卷 / 03期
基金：
中国国家自然科学基金;
关键词：
superoxide; hydrogen peroxide; electron leak; proton leak; H+/2e; membrane potential; reactive oxygen cycle; heat production; mitochondria;
D O I：
10.1023/A:1027328510931
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, we proposed a hypothetical model of coexistence of ''Reactive oxygen cycle'' with Q cycle and H+ cycle in mitochondrial respiratory chain to combine both processes of univalent electron leak for production of superoxide and of proton leak across inner mitochondrial membrane. This review presents a more detailed description of this model and summarizes the supporting experimental evidence obtained.
引用
收藏
页码：259 / 272
页数：14
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