PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTIMICROBIAL DRUGS IN INTENSIVE CARE UNIT PATIENTS

被引：9

作者：

Macedo, Rodrigo Spineli ^{[1
]}

Onita, Julio Henrique ^{[1
]}

Wille, Marcos Paulo ^{[1
]}

Campos Furtado, Guilherme Henrique ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Div Infect Dis, Antimicrobial Res Grp, Sao Paulo, Brazil

来源：

SHOCK | 2013年 / 39卷 / 07期

关键词：

Pharmacokinetics; pharmacodynamics; antimicrobial drugs; intensive care unit; CRITICALLY-ILL PATIENTS; VENTILATOR-ASSOCIATED PNEUMONIA; TARGET SITE PENETRATION; INHIBITORY CONCENTRATION; PIPERACILLIN-TAZOBACTAM; CONTINUOUS-INFUSION; PROTEIN-BINDING; RENAL-FUNCTION; SEPTIC SHOCK; BETA-LACTAMS;

D O I：

10.1097/SHK.0b013e31828faec0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Inappropriate use of antimicrobial drugs is responsible for therapeutic failures, increased mortality rates, and the emergence of resistance. Antimicrobial activity is determined by intrinsic pharmacokinetics/pharmacodynamics concepts. In critically ill patients, an inappropriate dosing regimen can be caused by the inability of an antimicrobial drug to reach adequate concentrations at the infection site owing to alterations in the drug's pharmacokinetics caused by pathophysiological changes. Understanding these concepts and changes in PK-PD parameters that occur in intensive care unit patients is crucial for the optimization of antimicrobial therapy in these patients.

引用

页码：24 / 28

页数：5

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