Evaluation of the AGE/sRAGE Axis in Patients with Multiple Myeloma

被引：14

作者：

Allegra, Alessandro ^{[1
]}

Musolino, Caterina ^{[1
]}

Pace, Elisabetta ^{[2
]}

Innao, Vanessa ^{[1
]}

Di Salvo, Eleonora ^{[3
]}

Ferraro, Maria ^{[2
]}

Casciaro, Marco ^{[4
]}

Spatari, Giovanna ^{[5
]}

Tartarisco, Gennaro ^{[3
]}

Allegra, Andrea Gaetano ^{[1
]}

Gangemi, Sebastiano ^{[4
]}

机构：

[1] Univ Messina, Dept Human Pathol Adulthood & Childhood Gaetano B, Div Hematol, I-98125 Messina, Italy

[2] Natl Res Council CNR, Inst Biomed & Mol Immunol A Monroy IBIM, I-90146 Palermo, Italy

[3] Natl Res Council Italy CNR, Inst Appl Sci & Intelligent Syst ISASI, I-98164 Messina, Italy

[4] Univ Messina, Sch & Operat Unit Allergy & Clin Immunol, Dept Clin & Expt Med, I-98125 Messina, Italy

[5] Univ Messina, Dept Biomed Sci Dent Morphol & Funct Invest, I-98125 Messina, Italy

来源：

ANTIOXIDANTS | 2019年 / 8卷 / 03期

关键词：

advanced glycation end products; soluble receptor of advanced glycation end products; oxidation; multiple myeloma; GLYCATION END-PRODUCTS; OXIDATION PROTEIN PRODUCTS; SOLUBLE FORM SRAGE; SERUM-LEVELS; ENDPRODUCTS AGES; BREAST-CANCER; RECEPTOR; RAGE; INFLAMMATION; STRESS;

D O I：

10.3390/antiox8030055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycative stress influences tumor progression. The aim of the present study was to evaluate the advanced glycation end products/soluble receptor of advanced glycation end products (AGE/sRAGE) axis in patients with multiple myeloma (MM). Blood samples were taken from 19 patients affected by MM and from 16 sex-matched and age-matched healthy subjects. AGE and sRAGE axis were dosed in patients with MM and matched with controls. AGEs were measured by spectrofluorimetric methods. Blood samples for the determination of sRAGE were analyzed by ELISA. AGE levels were significantly reduced in patients with respect to controls. Instead, sRAGE was significantly elevated in patients affected by MM compared to healthy subjects. Moreover, we showed that there was a statistically significant difference in sRAGE according to the heavy and light chain. IgA lambda had significantly higher sRAGE values than IgA kappa, IgG kappa, and IgG Lambda MM patients. From our data emerges the role of the sRAGE/AGE axis in MM. Since AGE is a positive regulator of the activity of RAGE, circulating sRAGE concentrations may reflect RAGE expression and may be raised in parallel with serum AGE concentrations as a counter-system against AGE-caused tissue damage. Serum concentrations of AGE and sRAGE could therefore become potential therapeutic targets.

引用

页数：11

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