Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

被引：50

作者：

Vijaykumar, Theophillis S. ^{[2
]}

Nath, Avindra ^{[2
]}

Chauhan, Ashok ^{[1
]}

机构：

[1] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

[2] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

来源：

VIROLOGY | 2008年 / 381卷 / 01期

关键词：

HIV-astrocyte; Lysosomotropic agents; HIV-reservoir;

D O I：

10.1016/j.virol.2008.07.039

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocyres to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocyres and may eventually facilitate early onset of neurological complications. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

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