Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis

被引：18
作者：
Rathore, Kusum
Wang, Hwa-Chain Robert [1 ]
机构：
[1] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, Knoxville, TN 37996 USA
来源：
CANCER LETTERS | 2013年 / 333卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Breast cell carcinogenesis; Cancer stem-like cells; Epithelial-to-mesenchymal transition; Intervention of carcinogenesis; Low-dose carcinogens; POLYCYCLIC AROMATIC-HYDROCARBONS; TOBACCO-SMOKE CARCINOGENS; EPITHELIAL-CELLS; ACTIVE SMOKING; STEM/PROGENITOR CELLS; CALIFORNIA TEACHERS; CHRONIC EXPOSURE; PASSIVE SMOKING; LUNG CARCINOGEN; MAMMARY-GLAND;
D O I：
10.1016/j.canlet.2013.01.030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Stem-like cells and the epithelial-to-mesenchymal transition (EMT) program are postulated to play important roles in various stages of cancer development, but their roles in breast cell carcinogenesis and intervention remain to be clarified. We investigated stem-like cell- and EMT-associated properties and markers in breast epithelial cells chronically exposed to low-dose 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene in the presence and absence of the preventive agents green tea catechins and grape seed extract. Our results indicate that stem-like cell- and EMT-associated properties and markers should be seriously considered as new cancer-associated indicators for detecting breast cell carcinogenesis and as endpoints for intervention of carcinogenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：113 / 123
页数：11
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