Palladium-Catalyzed C(sp2)-H Activation for the Formation of C-N Bonds: Rapid Access to Benzimidazoquinazolines

被引：12
作者：
Guo, Xiaolong [1 ]
Hu, Jing [1 ]
Zhang, Mengmeng [1 ]
Wang, Luyao [1 ]
机构：
[1] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 03期
基金：
北京市自然科学基金;
关键词：
benzimidazoles; palladium; C-H activation; C-N coupling; benzimidazoquinazolines; DIRECTING GROUP; COPPER; FUNCTIONALIZATION; DERIVATIVES; INHIBITORS; QUINAZOLINES; CHEMISTRY; ARYLATION; DESIGN;
D O I：
10.1002/ajoc.201800710
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and effective method for Pd-catalyzed cross-dehydrogenative C(sp(2))-H/N-H couplings to synthesize fused N-heterocyclic benzimidazoquinazoline derivatives was developed. The reaction employs Pd(OAc)(2) as the catalyst and Cu(OAc)(2) or O-2 (from the air) as the terminal oxidant. The strategy uses simple and easily accessible substrates. This method provides a route to azole-fused heterocycles.
引用
收藏
页码：417 / 421
页数：5
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