Palladium-Catalyzed C(sp2)-H Activation for the Formation of C-N Bonds: Rapid Access to Benzimidazoquinazolines

被引：12

作者：

Guo, Xiaolong ^{[1
]}

Hu, Jing ^{[1
]}

Zhang, Mengmeng ^{[1
]}

Wang, Luyao ^{[1
]}

机构：

[1] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 03期

基金：

北京市自然科学基金;

关键词：

benzimidazoles; palladium; C-H activation; C-N coupling; benzimidazoquinazolines; DIRECTING GROUP; COPPER; FUNCTIONALIZATION; DERIVATIVES; INHIBITORS; QUINAZOLINES; CHEMISTRY; ARYLATION; DESIGN;

D O I：

10.1002/ajoc.201800710

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and effective method for Pd-catalyzed cross-dehydrogenative C(sp(2))-H/N-H couplings to synthesize fused N-heterocyclic benzimidazoquinazoline derivatives was developed. The reaction employs Pd(OAc)(2) as the catalyst and Cu(OAc)(2) or O-2 (from the air) as the terminal oxidant. The strategy uses simple and easily accessible substrates. This method provides a route to azole-fused heterocycles.

引用

页码：417 / 421

页数：5

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