Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis

被引：115
作者：
Weide, B. [1 ]
Elsaesser, M. [1 ]
Buettner, P. [2 ]
Pflugfelder, A. [1 ]
Leiter, U. [1 ]
Eigentler, T. K. [1 ]
Bauer, J. [1 ]
Witte, M. [3 ]
Meier, F. [1 ]
Garbe, C. [1 ,2 ]
机构：
[1] Univ Med Ctr, Ctr Dermatooncol, Dept Dermatol, D-72076 Tubingen, Germany
[2] James Cook Univ, Skin Canc Res Grp, Sch Publ Hlth Trop Med & Rehabil Sci, Townsville, Qld 4811, Australia
[3] Univ Med Ctr, Dept Gen & Transplant Surg, D-72076 Tubingen, Germany
来源：
BRITISH JOURNAL OF CANCER | 2012年 / 107卷 / 03期
关键词：
lactate dehydrogenase; melanoma; metastasectomy; prognosis; S100; STAGE-IV-MELANOMA; AMERICAN JOINT COMMITTEE; ONCOLOGY-GROUP TRIALS; MALIGNANT-MELANOMA; PROGNOSTIC-FACTORS; SURGICAL-TREATMENT; GERMAN GUIDELINES; SURVIVAL; PROTEIN; S100-BETA;
D O I：
10.1038/bjc.2012.306
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Established prognostic factors are of limited value to predict long-term survival and benefit from metastasectomy in advanced melanoma. This study aimed to identify prognostic factors in patients with distant metastasis. METHODS: We analysed overall survival of 855 institutional melanoma patients with distant metastasis by bivariate Kaplan-Meier survival probabilities and multivariate Cox hazard regression analysis. RESULTS: Serum lactate dehydrogenases (LDH), S100B, the interval between initial diagnosis and occurrence of distant metastasis, the site of distant metastases, and the number of involved distant sites were significant independent prognostic factors in both bivariate and multivariate analyses. Visceral metastases other than lung (hazard ratio (HR) 1.8), elevated S100B (HR 1.7) and elevated LDH (HR 1.6) had the highest negative impact on survival. Complete metastasectomy was likewise an independent prognostic factor in multivariate analysis. This treatment was associated with favourable survival for patients with normal LDH and S100B values (5-year survival, 37.2%). CONCLUSION: The serum markers LDH and S100B were both found to be prognostic factors in melanoma patients with distant metastasis. Furthermore, complete metastasectomy had an independent favourable prognostic impact in particular for the patient subgroup with normal LDH and S100B values. British Journal of Cancer (2012) 107, 422-428. doi: 10.1038/bjc.2012.306 www.bjcancer.com Published online 10 July 2012 (C) 2012 Cancer Research UK
引用
收藏
页码：422 / 428
页数：7
相关论文
共 37 条
[11]   Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma [J].
Garbe, Claus ;
Hauschild, Axel ;
Volkenandt, Matthias ;
Schadendorf, Dirk ;
Stolz, Wilhelm ;
Reinhold, Uwe ;
Kortmann, Rolf-Dieter ;
Kettelhack, Christoph ;
Frerich, Bernhard ;
Keilholz, Ulrich ;
Dummer, Reinhard ;
Sebastian, Guenther ;
Tilgenf, Wolfgang ;
Schuler, Gerold ;
Mackensen, Andreas ;
Kaufmann, Roland .
MELANOMA RESEARCH, 2008, 18 (01) :61-67
[12]   Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma [J].
Garbe, Claus ;
Hauschild, Axel ;
Volkenandt, Matthias ;
Schadendorf, Dirk ;
Stolz, Wilhelm ;
Reinhold, Uwe ;
Kortmann, Rolf-Dieter ;
Kettelhack, Christoph ;
Frerich, Bernhard ;
Keilholz, Ulrich ;
Dummer, Reinhard ;
Sebastian, Guenther ;
Tilgen, Wolfgang ;
Schuler, Gerold ;
Mackensen, Andreas ;
Kaufmann, Roland .
MELANOMA RESEARCH, 2007, 17 (06) :393-399
[13]   Active secretion of S100B from astrocytes during metabolic stress [J].
Gerlach, R. ;
Demel, G. ;
Koenig, H. G. ;
Gross, U. ;
Prehn, J. H. M. ;
Raabe, A. ;
Seifert, V. ;
Koegel, D. .
NEUROSCIENCE, 2006, 141 (04) :1697-1701
[14]   Prognostic significance of serum S100B detection compared with routine blood parameters in advanced metastatic melanoma patients [J].
Hauschild, A ;
Michaelsen, J ;
Brenner, W ;
Gläser, R ;
Henze, E ;
Christophers, E .
MELANOMA RESEARCH, 1999, 9 (02) :155-161
[15]   REGRESSION-ANALYSES OF PROGNOSTIC FACTORS IN METASTATIC MALIGNANT-MELANOMA [J].
HEIMDAL, K ;
HANNISDAL, E ;
GUNDERSEN, S .
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1989, 25 (08) :1219-1223
[16]   NDR kinases regulate essential cell processes from yeast to humans [J].
Hergovich, A ;
Stegert, MR ;
Schmitz, D ;
Hemmings, BA .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (04) :253-264
[17]   Improvement of overall survival of patients with cutaneous melanoma in Germany, 1976-2001 - Which factors contributed? [J].
Lasithiotakis, Konstantinos G. ;
Leiter, Ulrike ;
Eigentler, Thomas ;
Breuninger, Helmut ;
Metzler, Gisela ;
Meier, Friedegund ;
Garbe, Claus .
CANCER, 2007, 109 (06) :1174-1182
[18]   Lung metastases from melanoma: when is surgical treatment warranted? [J].
Leo, F ;
Cagini, L ;
Rocmans, P ;
Cappello, M ;
Van Geel, AN ;
Maggi, G ;
Goldstraw, P ;
Pastorino, U .
BRITISH JOURNAL OF CANCER, 2000, 83 (05) :569-572
[19]   Prognostic factors in metastatic melanoma: A pooled analysis of Eastern Cooperative Oncology Group trials [J].
Manola, J ;
Atkins, M ;
Ibrahim, J ;
Kirkwood, J .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (22) :3782-3793
[20]  
Meyer T, 2000, CANCER, V89, P1983, DOI 10.1002/1097-0142(20001101)89:9<1983::AID-CNCR15>3.3.CO
1234