Bile reflux and bile acids in the progression of gastric intestinal metaplasia

被引：11
作者：
Qu, Xiaodong [1 ]
Shi, Yongquan [1 ]
机构：
[1] Air Force Med Univ, Xijing Hosp, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2022年 / 135卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Bile adds; Bile reflux; Farnesoid X receptor; Gastric intestinal metaplasia; Hepatocyte nuclear factor 4 alpha; Methylation; Nuclear factor-kappa B; HELICOBACTER-PYLORI ERADICATION; VITAMIN-D-RECEPTOR; TRANSCRIPTION FACTOR; CHINESE POPULATION; ECTOPIC EXPRESSION; ATROPHIC GASTRITIS; NUCLEAR RECEPTORS; TRANSGENIC MICE; HUMAN STOMACH; RISK-FACTORS;
D O I：
10.1097/CM9.0000000000002290
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gastric intestinal metaplasia (WM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC. Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process. Bile reflux is also a pathogenic factor in GIM and can continuously irritate the gastric mucosa, and bile acids in refluxed fluid have been widely reported to be associated with GIM. This paper reviews in detail the relationship between bile reflux and GIM and the mechanisms by which bile acids induce GIM.
引用
收藏
页码：1664 / 1672
页数：9
相关论文
共 50 条
  • [31] Ethnicity Is an Important Consideration in Screening for Gastric Intestinal Metaplasia
    Kligman, Eugene
    Ali, Hiba
    Chen, Ellie
    Peng, Frederick
    Szafron, David
    Staggers, Kristen
    Tan, Mimi C.
    Patel, Kalpesh
    Othman, Mohamed O.
    DIGESTIVE DISEASES AND SCIENCES, 2022, 67 (09) : 4509 - 4517
  • [32] Gastric Intestinal Metaplasia: An Intermediate Precancerous Lesion in the Cascade of Gastric Carcinogenesis
    Malik, Tayyab Hamid
    Al Sayahan, Mujtaba Yousef
    Al Ahmed, Hussain Ali
    Hong, Xu
    JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 2017, 27 (03): : 166 - 172
  • [33] Histological features of the gastric mucosa in children with primary bile reflux gastritis
    Zhang, Yanyi
    Yang, Xi
    Gu, Weizhong
    Shu, Xiaoli
    Zhang, Ting
    Jiang, Mizu
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2012, 10
  • [34] Bile Reflux is a Common Finding in the Gastric Pouch After One Anastomosis Gastric Bypass
    Tuure Saarinen
    Kirsi H. Pietiläinen
    Antti Loimaala
    Toni Ihalainen
    Henna Sammalkorpi
    Anne Penttilä
    Anne Juuti
    Obesity Surgery, 2020, 30 : 875 - 881
  • [35] Histological features of the gastric mucosa in children with primary bile reflux gastritis
    Yanyi Zhang
    Xi Yang
    Weizhong Gu
    Xiaoli Shu
    Ting Zhang
    Mizu Jiang
    World Journal of Surgical Oncology, 10
  • [36] Bile Reflux is a Common Finding in the Gastric Pouch After One Anastomosis Gastric Bypass
    Saarinen, Tuure
    Pietilainen, Kirsi H.
    Loimaala, Antti
    Ihalainen, Toni
    Sammalkorpi, Henna
    Penttila, Anne
    Juuti, Anne
    OBESITY SURGERY, 2020, 30 (03) : 875 - 881
  • [37] Gastric pathology in cholecystectomy patients:: Role of Helicobacter pylori and bile reflux
    Zullo, A
    Rinaldi, V
    Hassan, C
    Lauria, V
    Attili, AF
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 1998, 27 (04) : 335 - 338
  • [38] The Impact of Cholecystectomy on Bile Reflux After One Anastomosis Gastric Bypass
    Farzadmanesh, Mohammad Javad
    Shahsavan, Masoumeh
    Shahmiri, Shahab Shahabi
    Ghorbani, Mahsa
    Fathi, Mohammad
    Mehrnia, Nariman
    Pazouki, Abdolreza
    Kermansaravi, Mohammad
    OBESITY SURGERY, 2025, 35 (01) : 78 - 86
  • [39] Bile acids and neurological disease
    Hurley, Michael J.
    Bates, Rachel
    Macnaughtan, Jane
    Schapira, Anthony H. V.
    PHARMACOLOGY & THERAPEUTICS, 2022, 240
  • [40] Bile acids as metabolic regulators
    Li, Tiangang
    Chiang, John Y. L.
    CURRENT OPINION IN GASTROENTEROLOGY, 2015, 31 (02) : 159 - 165
12345