Bile reflux and bile acids in the progression of gastric intestinal metaplasia

被引：10
|
作者：
Qu, Xiaodong [1 ]
Shi, Yongquan [1 ]
机构：
[1] Air Force Med Univ, Xijing Hosp, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2022年 / 135卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Bile adds; Bile reflux; Farnesoid X receptor; Gastric intestinal metaplasia; Hepatocyte nuclear factor 4 alpha; Methylation; Nuclear factor-kappa B; HELICOBACTER-PYLORI ERADICATION; VITAMIN-D-RECEPTOR; TRANSCRIPTION FACTOR; CHINESE POPULATION; ECTOPIC EXPRESSION; ATROPHIC GASTRITIS; NUCLEAR RECEPTORS; TRANSGENIC MICE; HUMAN STOMACH; RISK-FACTORS;
D O I：
10.1097/CM9.0000000000002290
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gastric intestinal metaplasia (WM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC. Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process. Bile reflux is also a pathogenic factor in GIM and can continuously irritate the gastric mucosa, and bile acids in refluxed fluid have been widely reported to be associated with GIM. This paper reviews in detail the relationship between bile reflux and GIM and the mechanisms by which bile acids induce GIM.
引用
收藏
页码：1664 / 1672
页数：9
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