Urine Concentrating and Diluting Ability During Aging

被引:51
作者
Sands, Jeff M. [1 ,2 ]
机构
[1] Emory Univ, Sch Med, Dept Med, Div Renal, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2012年 / 67卷 / 12期
基金
美国国家卫生研究院;
关键词
Vasopressin; Aquaporin; Water channels; Urea transporters; sodium transport; REGULATED UREA TRANSPORTER; AGE-RELATED POLYURIA; DOWN-REGULATION; AQUAPORIN-2; PHOSPHORYLATION; NOCTURNAL POLYURIA; FEEDING PROTEIN; COLLECTING DUCT; OLDER-ADULTS; V2; RECEPTOR; VASOPRESSIN;
D O I
10.1093/gerona/gls128
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Urine concentrating ability is reduced during normal aging in people and rats. The abundance of many of the key transport proteins that contribute to urine concentrating ability is reduced in the kidney medulla of aged rats. The reductions in water, sodium, and urea transport protein abundances, and their reduced response to water restriction, contribute to the reduced ability of aged rats to concentrate their urine and conserve water. If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced urine concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability and/or nocturnal polyuria.
引用
收藏
页码:1352 / 1357
页数:6
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