This paper describes four cases of localized bullous separation of Descemet's membrane that occurred from more than 1 year to 7 years after cataract surgery. In all eyes, fluid resembling a hypopyon (pseudohypopyon) filled the space created by the separation. In three cases, the fluid was white. In one of these, pathological examination of the fluid showed mostly necrotic but a few viable squamous epithelial cells. In the fourth case in which the fluid was whitish red, there were many capillaries along the edge of the separation and there was evidence of injury to the nearby epithelium. The one case with poor visual acuity improved after the fluid was removed.