The influence of MTHFR C677T polymorphism in chronic lymphocytic leukemia

被引：6

作者：

da Silva Reis, Angela Adamski ^{[1
]}

de Alcantara, Keila Correia ^{[2
]}

Cordeiro de Farias, Danielle Leao ^{[3
]}

Borges dos Anjos, Laura Raniere ^{[1
]}

Rodrigues, Debora Acyole ^{[1
]}

Pedrino, Gustavo Rodrigues ^{[4
]}

Santos, Rodrigo da Silva ^{[1
,5
]}

机构：

[1] Univ Fed Goias, Lab Mol Pathol, Inst Biol Sci, Goiania, Go, Brazil

[2] Univ Fed Goias, Fac Pharm, Goiania, Go, Brazil

[3] Univ Fed Goias, Hematol Serv, Clin Hosp, Goiania, Go, Brazil

[4] Univ Fed Goias, Biol Sci Inst, Esperanca Ave,Campus 2, Goiania, Go, Brazil

[5] Univ Fed Goias, Dept Nat Sci LEdoC, Special Acad Unit Human Sci, Goiania, Go, Brazil

来源：

ELECTROPHORESIS | 2019年 / 40卷 / 12-13期

关键词：

Central Brazilian population; Chronic lymphocytic leukemia; Methylenetetrahydrofolate reductase C677T polymorphism; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; RISK; GENE; DIAGNOSIS; MUTATION; FOLATE;

D O I：

10.1002/elps.201800402

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Some factors have been associated with the etiology of chronic lymphocytic leukemia (CLL), among them the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. The aim of this study was to evaluate the role of MTHFR C677T polymorphism in CLL. A case-control study was conducted with 219 individuals from Brazilian central population. MTHFR C677T polymorphism was determined through PCR-RFLP followed by PAGE. The T allele frequence was higher in patients diagnosed with CLL than healthy subjects. However, when stratified by gender, the TT genotype was exclusively found in men diagnosed with CLL (p < 0.05). Adjusted multiple logistic regression analysis demonstrated that age was significantly linked to CLL predisposition (odds ratio = 1.08; p < 0.001). Studies evaluating the influence of genetic factors may provide insights on susceptibility for CLL.

引用

页码：1715 / 1718

页数：4

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