Pancreas transplantation: a single-institution experience in Japan

被引:14
作者
Okabe, Yasuhiro [1 ]
Kitada, Hidehisa [1 ]
Miura, Yoshifumi [1 ]
Nishiki, Takehiro [1 ]
Kurihara, Kei [1 ]
Kawanami, Sayako [1 ]
Terasaka, Soshi [1 ]
Kaku, Keizo [1 ]
Noguchi, Hiroshi [1 ]
Sugitani, Atsushi [1 ]
Tanaka, Masao [1 ]
机构
[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Higashi Ku, Fukuoka 8128582, Japan
关键词
Pancreas transplantation; Venous thrombosis; Risk factor; VASCULAR GRAFT THROMBOSIS; ALLOGRAFT THROMBOSIS; RISK-FACTORS; OUTCOMES; REGISTRY; DONORS; IMPACT;
D O I
10.1007/s00595-013-0516-6
中图分类号
R61 [外科手术学];
学科分类号
摘要
We herein report our experience with pancreas transplantation in 26 patients at a single institution in Japan between August 2001 and December 2011. We reviewed the medical records of 26 pancreas transplantations performed in our institute. The early complications (within 2 weeks) included one graft venous thrombosis, one arterial thrombosis, and two reoperations for bleeding. Of the 26 pancreas transplant recipients, five lost pancreas graft function. Of 24 simultaneous pancreas-kidney recipients, three lost kidney graft function due to noncompliance. The patient, pancreas, and kidney survival rates were 100, 96 and 93 % at 1 year; 100, 80 and 93 % at 5 years; and 100, 67 and 68 % at 10 years, respectively. Of all these complications, venous thrombosis after pancreas transplantation was the most critical. As the largest series of pancreas transplantations in a single institution in Japan, our series yielded better results than the worldwide data recorded by the International Pancreas Transplant Registry. Routine postoperative anticoagulation therapy is not necessary for the prevention of graft thrombosis if sufficient fluid infusion is strictly controlled and the graft blood flow is frequently monitored. When graft thrombosis occurs, both early detection and appropriate intervention are extremely important if the pancreas graft is to survive.
引用
收藏
页码:1406 / 1411
页数:6
相关论文
共 21 条
  • [1] Pancreas graft thrombosis - Is there a role for trypsin
    Benz, S
    Busing, M
    Kruger, B
    Mayer, JM
    Obermaier, R
    Keck, T
    Pfeffer, F
    Hopt, UT
    [J]. PANCREAS, 2004, 28 (01) : 75 - 79
  • [2] Hypercoagulable state associated with kidney-pancreas transplantation. Thromboelastogram-directed anti-coagulation and implications for future therapy
    Burke, GW
    Ciancio, G
    Figueiro, J
    Buigas, R
    Olson, L
    Roth, D
    Kupin, W
    Miller, J
    [J]. CLINICAL TRANSPLANTATION, 2004, 18 (04) : 423 - 428
  • [3] Treatment and outcome of pancreatic venous graft thrombosis after kidney-pancreas transplantation
    Gilabert, R
    Fernández-Cruz, L
    Real, MI
    Ricart, MJ
    Astudillo, E
    Montaña, X
    [J]. BRITISH JOURNAL OF SURGERY, 2002, 89 (03) : 355 - 360
  • [4] Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004
    Gruessner, AC
    Sutherland, DE
    [J]. CLINICAL TRANSPLANTATION, 2005, 19 (04) : 433 - 455
  • [5] Gruessner Angelika C, 2011, Rev Diabet Stud, V8, P6, DOI 10.1900/RDS.2011.8.6
  • [6] GRUESSNER RWG, 1994, TRANSPLANTATION, V57, P1598
  • [7] Immediate Retransplantation for Pancreas Allograft Thrombosis
    Hollinger, E. F.
    Powelson, J. A.
    Mangus, R. S.
    Kazimi, M. M.
    Taber, T. E.
    Goble, M. L.
    Fridell, J. A.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 (04) : 740 - 745
  • [8] Decreased surgical risks of pancreas transplantation in the modern era
    Humar, A
    Kandaswamy, R
    Granger, D
    Gruessner, RW
    Gruessner, AC
    Sutherland, DER
    [J]. ANNALS OF SURGERY, 2000, 231 (02) : 269 - 275
  • [9] Technical failures after pancreas transplants: Why grafts fail and the risk factors - A multivariate analysis
    Humar, A
    Ramcharan, T
    Kandaswamy, R
    Gruessner, RWG
    Gruessner, AC
    Sutherland, DER
    [J]. TRANSPLANTATION, 2004, 78 (08) : 1188 - 1192
  • [10] The impact of donor obesity on outcomes after cadaver pancreas transplants
    Humar, A
    Ramcharan, T
    Kandaswamy, R
    Gruessner, RWG
    Gruessner, AG
    Sutherland, DER
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (04) : 605 - 610