OXA-48-like carbapenemases producing Enterobacteriaceae in different niches

被引:154
作者
Mairi, Assia [1 ,2 ]
Pantel, Alix [2 ,3 ]
Sotto, Albert [2 ]
Lavigne, Jean-Philippe [2 ,3 ]
Touati, Aziz [1 ]
机构
[1] Univ Bejaia, FSNV, Lab Ecol Microbienne, Bejaia 06000, Algeria
[2] Univ Montpellier, UFR Med, Inst Natl Sante & Rech Med, U1047, 186 Chemin Carreau Lanes,CS83021, F-30908 Montpellier, France
[3] Univ Hosp Nimes, Dept Microbiol, Nimes, France
关键词
Carbapenemase; Enterobacteriaceae; Environment; Niches; OXA-48-like; Persistence; OXA-48-PRODUCING KLEBSIELLA-PNEUMONIAE; SPECTRUM BETA-LACTAMASE; GRAM-NEGATIVE BACILLI; OXACILLINASE-MEDIATED RESISTANCE; ESBL-PRODUCING ENTEROBACTERIACEAE; ISOLATES PRODUCING OXA-48; TERTIARY CARE CENTER; CO-PRODUCING NDM-7; ESCHERICHIA-COLI; 1ST REPORT;
D O I
10.1007/s10096-017-3112-7
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D beta-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences. To date, 11 OXA-48-like variants have been identified, with classical OXA-48 being the most widespread. These enzymes show high-level hydrolytic activity against penicillins and low-level hydrolysis towards carbapenems. Since the first description of the OXA-48 carbapenemase in Turkey, bacterial strains producing the enzyme have been extensively reported in nosocomial and community outbreaks in many parts of the word, particularly in the Mediterranean area and European countries. The rapid spread of Enterobacteriaceae producing OXA-48-like enzymes in different ecosystems has become a serious issue recently. The number of reservoirs for such organisms is increasing, not only in hospitals, but also in the community, among animals (e.g., livestock, companion animals, and wildlife) and in the environment. This review aims to summarize the main characteristics of the OXA-48-type carbapenemases, covering genetic and enzymatic traits, their epidemiology, clonality and associated genes, correlation with extended-spectrum beta-lactamases (ESBLs) or plasmidic AmpC (pAmpC) in different bacterial species worldwide.
引用
收藏
页码:587 / 604
页数:18
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