Dual role of the adaptor protein SLP-65 - Organizer of signal transduction and tumor suppressor of pre-B cell leukemia

被引：4

作者：

Herzog, Sebastian ^{[1
]}

Storch, Bettina ^{[1
]}

Jumaa, Hassan ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany

来源：

IMMUNOLOGIC RESEARCH | 2006年 / 34卷 / 02期

关键词：

B cell development; leukemia; tumor suppressor; SLP-65; Btk;

D O I：

10.1385/IR:34:2:143

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cell development is characterized by a coordinated progression through defined stages that are controlled at several checkpoints. Signals from the pre-B cell receptor (pre-BCR) are essential for regulated transition from the pre-B cell stage. The adaptor protein SLP-65 plays a key role in this signaling pathway. Recent findings indicate an additional function of SLP-65 as a tumor suppressor that regulates pre-B cell proliferation. We will discuss here the potential mechanisms by which SLP-65 controls the pre-B cell checkpoint.

引用

页码：143 / 155

页数：13

共 72 条

[1] BLNK mediates Syk-dependent Btk activation [J].

Baba, Y ;

Hashimoto, S ;

Matsushita, M ;

Watanabe, D ;

Kishimoto, T ;

Kurosaki, T ;

Tsukada, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2582-2586

[2] Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis [J].

Bannish, G ;

Fuentes-Pananá, EM ;

Cambier, JC ;

Pear, WS ;

Monroe, JG .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (11) :1583-1596

[3] Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines [J].

Bradl, H ;

Jäck, HM .

JOURNAL OF IMMUNOLOGY, 2001, 167 (11) :6403-6411

[4] Non-T cell activation linker (NTAL):: A transmembrane adaptor protein involved in immunoreceptor signaling [J].

Brdicka, T ;

Imrich, M ;

Angelisová, P ;

Brdicková, N ;

Horváth, O ;

Spicka, J ;

Hilgert, I ;

Lusková, P ;

Dráber, P ;

Novák, P ;

Engels, N ;

Wienands, J ;

Simeoni, L ;

Österreicher, J ;

Aguado, E ;

Malissen, M ;

Schraven, B ;

Horejsí, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (12) :1617-1626

[5] SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 [J].

Carrano, AC ;

Eytan, E ;

Hershko, A ;

Pagano, M .

NATURE CELL BIOLOGY, 1999, 1 (04) :193-199

[6] A role for lipid rafts in B cell antigen receptor signaling and antigen targeting [J].

Cheng, PC ;

Dykstra, ML ;

Mitchell, RN ;

Pierce, SK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) :1549-1560

[7] BLNK:: molecular scaffolding through 'cis'-mediated organization of signaling proteins [J].

Chiu, CW ;

Dalton, M ;

Ishiai, M ;

Kurosaki, T ;

Chan, AC .

EMBO JOURNAL, 2002, 21 (23) :6461-6472

[8] p62dok, a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210bcr-abl [J].

Di Cristofano, A ;

Niki, M ;

Zhao, MM ;

Karnell, FG ;

Clarkson, B ;

Pear, WS ;

Van Aelst, L ;

Pandolfi, PP .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (03) :275-284

[9] PHOSPHORYLATION OF GAP AND GAP-ASSOCIATED PROTEINS BY TRANSFORMING AND MITOGENIC TYROSINE KINASES [J].

ELLIS, C ;

MORAN, M ;

MCCORMICK, F ;

PAWSON, T .

NATURE, 1990, 343 (6256) :377-381

[10] The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion [J].

Flemming, A ;

Brummer, T ;

Reth, M ;

Jumaa, H .

NATURE IMMUNOLOGY, 2003, 4 (01) :38-43

← 1 2 3 4 5 6 7 8 →