MicroRNAs in malignant melanoma

被引：23

作者：

Voeller, Daniel ^{[1
]}

Ott, Corinna ^{[1
]}

Bosserhoff, Anja ^{[1
]}

机构：

[1] Univ Regensburg, Inst Pathol, D-93053 Regensburg, Germany

来源：

CLINICAL BIOCHEMISTRY | 2013年 / 46卷 / 10-11期

关键词：

Melanoma; MiRNAs; Diagnostic; Therapy; CELL-PROLIFERATION; TRANSCRIPTION FACTOR; CUTANEOUS MELANOMA; THERAPEUTIC TARGET; TUMOR PROGRESSION; GENE-EXPRESSION; DOWN-REGULATION; CANCER-CELLS; BODY-FLUIDS; E-CADHERIN;

D O I：

10.1016/j.clinbiochem.2013.01.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Melanoma is the most aggressive form of skin cancer, and the incidence of melanoma has been increasing faster than that of most other cancers. While the survival rate following surgical resection of early-stage primary tumors is nearly 100%, the survival of patients with metastasized tumors is strongly reduced, likely due to resistance to conventional therapies. Therefore, it is important to use new molecular approaches to develop new biomarkers to better prevent and diagnose melanoma. MicroRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate gene expression via repression of translation or direct degradation of their complementary mRNA. In this review, we summarize our current understanding of the involvement of miRNAs and their corresponding targets in melanomagenesis as well as the potential use of miRNAs as biomarkers. (c) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：909 / 917

页数：9

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