Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development

被引：44

作者：

Brand, T ^{[1
]}

Andree, B ^{[1
]}

Schneider, A ^{[1
]}

Buchberger, A ^{[1
]}

Arnold, HH ^{[1
]}

机构：

[1] TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG,DEPT CELL & MOL BIOL,D-38106 BRAUNSCHWEIG,GERMANY

来源：

MECHANISMS OF DEVELOPMENT | 1997年 / 64卷 / 1-2期

关键词：

NK-2; homeobox; chicken; heart; branchial arch;

D O I：

10.1016/S0925-4773(97)00044-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

cNkx2-8 represents a novel member of the NK2-family of transcription factors. The gene contains three highly conserved regions, the TN-, NK2-, and homeodomains which are diagnostic for this group of proteins. cNkx2-8 is expressed during chick embryogenesis in ventral foregut endoderm, myocardial mesoderm, epithelium of the branchial arches and the dorsal mesocardium. While cNkx2-8 expression partially overlaps with other NK genes, such as Nkx2-5 and Nkx2-3, its onset and aspects of its expression domains are specific. Thus, structural data and the expression profile suggest that cNkx2-8 constitutes a new homeobox protein which may cooperate with its known relatives in defining an antero-ventral field including the developing heart and pharyngeal endoderm. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：53 / 59

页数：7