Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development

被引：44

作者：

Brand, T ^{[1
]}

Andree, B ^{[1
]}

Schneider, A ^{[1
]}

Buchberger, A ^{[1
]}

Arnold, HH ^{[1
]}

机构：

[1] TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG,DEPT CELL & MOL BIOL,D-38106 BRAUNSCHWEIG,GERMANY

来源：

MECHANISMS OF DEVELOPMENT | 1997年 / 64卷 / 1-2期

关键词：

NK-2; homeobox; chicken; heart; branchial arch;

D O I：

10.1016/S0925-4773(97)00044-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

cNkx2-8 represents a novel member of the NK2-family of transcription factors. The gene contains three highly conserved regions, the TN-, NK2-, and homeodomains which are diagnostic for this group of proteins. cNkx2-8 is expressed during chick embryogenesis in ventral foregut endoderm, myocardial mesoderm, epithelium of the branchial arches and the dorsal mesocardium. While cNkx2-8 expression partially overlaps with other NK genes, such as Nkx2-5 and Nkx2-3, its onset and aspects of its expression domains are specific. Thus, structural data and the expression profile suggest that cNkx2-8 constitutes a new homeobox protein which may cooperate with its known relatives in defining an antero-ventral field including the developing heart and pharyngeal endoderm. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：53 / 59

页数：7

共 33 条

[31] Myostatin and TGF-β2 gene expression patterns in response to in ovo administration of rhIGF-I during chicken embryonic development [J].

Kocamis, H ;

Gahr, SA ;

Richter, J ;

Kirkpatrick-Keller, DC ;

Killefer, J .

GROWTH DEVELOPMENT AND AGING, 2002, 66 (01) :3-10

[32] Six9 (Optx2), a new member of the Six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development [J].

López-Ríos, J ;

Gallardo, ME ;

de Córdoba, SR ;

Bovolenta, P .

MECHANISMS OF DEVELOPMENT, 1999, 83 (1-2) :155-159

[33] B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos: Universal versus species-dependent features [J].

Uchikawa, Masanori ;

Yoshida, Megumi ;

Iwafuchi-Doi, Makiko ;

Matsuda, Kazunari ;

Ishida, Yoshiko ;

Takemoto, Tatsuya ;

Kondoh, Hisato .

DEVELOPMENT GROWTH & DIFFERENTIATION, 2011, 53 (06) :761-771

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