Breast Carcinoma with a Special Histological Pattern of Sebaceous Differentiation and High-Frequency Microsatellite Instability: A Case Report and Review of the Literature

被引：0

作者：

Luo, Li ^{[1
]}

Hu, Yanping ^{[1
]}

Liu, Fengge ^{[1
]}

Yang, Jianjie ^{[1
]}

Bai, Yang ^{[1
]}

Meng, Yutong ^{[1
]}

Ding, Ran ^{[1
]}

Hu, Mingzhu ^{[1
]}

Wu, Linguo ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Luhe Hosp, Dept Pathol, 82 Xinhuanan Rd, Beijing 101149, Peoples R China

来源：

ANNALS OF CLINICAL AND LABORATORY SCIENCE | 2022年 / 52卷 / 05期

关键词：

breast carcinoma; sebaceous pattern; microsatellite instability; mismatch repair; PATIENT; TUMOR;

D O I：

10.2451/clin.5487

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The World Health Organization in its 2019 Classification of Breast Tumors termed breast sebaceous carcinoma as invasive breast carcinoma of no special type (IBC-NST), with a sebaceous pattern. Approximately 30 cases of IBC-NST with a sebaceous pattern have been reported in the literature, and in all cases the expression of mismatch repair proteins in tumors was normal. Here, we report a case of IBC-NST with a sebaceous pattern and high-frequency microsatellite instability (MSI-H). This case was a sporadic sebaceous pattern of IBC-NST with MSI-H and was unrelated to Muir-Torre syndrome. Its histopathological characteristics were similar to those of MSI-H-associated triple-negative breast carcinoma (TNBC) with a high histological grade but were without tumor-infiltrating lymphocytes (TILs). The tumor did not recur after 20 months of follow-up.

引用

页码：850 / 857

页数：8

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