Thermolides, Potent Nematocidal PKS-NRPS Hybrid Metabolites from Thermophilic Fungus Talaromyces thermophilus

被引：66

作者：

Guo, Ji-Peng

Zhu, Chun-Yan

Zhang, Chuan-Ping

Chu, Yan-Sheng

Wang, Yan-Li

Zhang, Jun-Xian

Wu, De-Kai

Zhang, Ke-Qin ^{[1
]}

Niu, Xue-Mei

机构：

[1] Yunnan Univ, Lab Conservat & Utilizat Bioresources, Minist Educ, Kunming 650091, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 50期

关键词：

NONRIBOSOMAL PEPTIDE ANTIBIOTICS; ABSOLUTE-CONFIGURATION; POLYKETIDE; NMR; ASSIGNMENT; ALKALOIDS; SEQUENCE; GENOME; LOGIC;

D O I：

10.1021/ja3104044

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macrocyclic PKS-NRPS hybrid metabolites represent a unique family of natural products mainly from bacteria with broad and outstanding biological activities. However, their distribution in fungi has rarely been reported, and little has been reported regarding their nematocidal activity. Here we describe an unprecedented class of PKS-NRPS hybrid metabolites possessing a 13-membered lactam-bearing macrolactone, thermolides A F (1-6) from a thermophilic fungus Talaromyces thermophilus. We showed that 1 and 2 displayed potent inhibitory activity against three notorious nematodes with LC50 values of 0.5-1 mu g/mL, as active as commercial avermectins. This work provided a new class of promising lead compounds for nematocide discovery.

引用

页码：20306 / 20309

页数：4

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