Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

被引：9

作者：

Laing, Kerry J. ^{[1
]}

Ouwendijk, Werner J. D. ^{[2
]}

Campbell, Victoria L. ^{[1
]}

McClurkan, Christopher L. ^{[1
]}

Mortazavi, Shahin ^{[1
]}

Waters, Michael Elder ^{[1
]}

Krist, Maxwell P. ^{[1
]}

Tu, Richard ^{[1
]}

Nguyen, Nhi ^{[1
]}

Basu, Krithi ^{[1
]}

Miao, Congrong ^{[3
]}

Schmid, D. Scott ^{[3
]}

Johnston, Christine ^{[1
,4
]}

Verjans, Georges M. G. M. ^{[2
]}

Koelle, David M. ^{[1
,4
,5
,6
,7
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Erasmus MC, HerpeslabNL Dept Virosci, Rotterdam, Netherlands

[3] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA

[4] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[5] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA

[6] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[7] Benaroya Res Inst, Dept Translat Res, Seattle, WA USA

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

关键词：

SIMPLEX-VIRUS; VARICELLA; CD4; INFECTION; IMMUNITY; ANTIGENS; MEMORY; HSV-2; VACCINATION; PREVENTION;

D O I：

10.1038/s41467-022-34698-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T cells are considered important for controlling skin infections. Here, the authors report that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in rash-involved skin after recovery from zoster. Herpes zoster is a localized skin infection caused by reactivation of latent varicella-zoster virus. Tissue-resident T cells likely control skin infections. Zoster provides a unique opportunity to determine if focal reinfection of human skin boosts local or disseminated antigen-specific tissue-resident T cells. Here, we show virus-specific T cells are retained over one year in serial samples of rash site and contralateral unaffected skin of individuals recovered from zoster. Consistent with zoster resolution, viral DNA is largely undetectable on skin from day 90 and virus-specific B and T cells decline in blood. In skin, there is selective infiltration and long-term persistence of varicella-zoster virus-specific T cells in the rash site relative to the contralateral site. The skin T cell infiltrates express the canonical tissue-resident T cell markers CD69 and CD103. These findings show that zoster promotes spatially-restricted long-term retention of antigen-specific tissue-resident T cells in previously infected skin.

引用

页数：13

共 69 条

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