Two photoactive Ru (II) compounds based on tetrazole ligands for photodynamic therapy

被引：14
作者：
Yang, Jie [1 ,2 ]
He, Xin [3 ]
Ke, Zhen [1 ]
Chen, Jianjiao [1 ]
Zou, Zhenyuan [1 ]
Wei, Bo [2 ]
Zou, Dengfeng [1 ]
Zou, Jianhua [2 ]
机构：
[1] Guilin Med Univ, Sch Pharm, Guilin 541004, Guangxi, Peoples R China
[2] Changshu Inst Technol, Dept Chem & Mat Engn, Jiangsu Key Lab Adv Funct Mat, Changshu 215500, Jiangsu, Peoples R China
[3] Nanjing Tech Univ, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2020年 / 210卷
关键词：
Ru(II); Tetrazole; HeLa; Photodynamic therapy; COMPLEXES; LIGHT;
D O I：
10.1016/j.jinorgbio.2020.111127
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ru (II) compounds have potential application in photodynamic therapy (PDT). In the current study, two Ru (II) compounds based on the auxiliary ligand 2,2 '-bipyridine (bipy) by changing main ligands 5-(2-pyridyl) tetrazole (Hpytz) and di(2H-tetrazol-5-yl) amine (H(2)datz) have been successfully synthesized and characterized, [Ru (pytz)(bipy)(2)][PF6] (1) and [Ru(Hdatz)(bipy)(2)][PF6] (2). These compounds can form nanoparticles (NPs) by nano-precipitation. And [Ru(pytz)(bipy)(2)][PF6] NPs with a lower half maximal inhibitory concentration (IC50) of 37 mu g/mL on HeLa cells than that of [Ru(Hdatz)(bipy)(2)][PF6] NPs (65 mu g/mL). Meanwhile, negligible dark toxicity has been also observed for these NPs even under high concentrations. The results show that [Ru(pytz) (bipy)(2)][PF6] (1) and [Ru(Hdatz)(bipy)(2)][PF6] (2) NPs can inhibit cell proliferation in vitro, and may be potential candidates for photodynamic therapy.
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页数：7
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