Two photoactive Ru (II) compounds based on tetrazole ligands for photodynamic therapy

被引：14

作者：

Yang, Jie ^{[1
,2
]}

He, Xin ^{[3
]}

Ke, Zhen ^{[1
]}

Chen, Jianjiao ^{[1
]}

Zou, Zhenyuan ^{[1
]}

Wei, Bo ^{[2
]}

Zou, Dengfeng ^{[1
]}

Zou, Jianhua ^{[2
]}

机构：

[1] Guilin Med Univ, Sch Pharm, Guilin 541004, Guangxi, Peoples R China

[2] Changshu Inst Technol, Dept Chem & Mat Engn, Jiangsu Key Lab Adv Funct Mat, Changshu 215500, Jiangsu, Peoples R China

[3] Nanjing Tech Univ, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2020年 / 210卷

关键词：

Ru(II); Tetrazole; HeLa; Photodynamic therapy; COMPLEXES; LIGHT;

D O I：

10.1016/j.jinorgbio.2020.111127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ru (II) compounds have potential application in photodynamic therapy (PDT). In the current study, two Ru (II) compounds based on the auxiliary ligand 2,2 '-bipyridine (bipy) by changing main ligands 5-(2-pyridyl) tetrazole (Hpytz) and di(2H-tetrazol-5-yl) amine (H(2)datz) have been successfully synthesized and characterized, [Ru (pytz)(bipy)(2)][PF6] (1) and [Ru(Hdatz)(bipy)(2)][PF6] (2). These compounds can form nanoparticles (NPs) by nano-precipitation. And [Ru(pytz)(bipy)(2)][PF6] NPs with a lower half maximal inhibitory concentration (IC50) of 37 mu g/mL on HeLa cells than that of [Ru(Hdatz)(bipy)(2)][PF6] NPs (65 mu g/mL). Meanwhile, negligible dark toxicity has been also observed for these NPs even under high concentrations. The results show that [Ru(pytz) (bipy)(2)][PF6] (1) and [Ru(Hdatz)(bipy)(2)][PF6] (2) NPs can inhibit cell proliferation in vitro, and may be potential candidates for photodynamic therapy.

引用

页数：7

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