Non-Enzymatic Dynamic Kinetic Resolution of Secondary Aryl Alcohols: Planar Chiral Ferrocene and Ruthenium Catalysts in Cooperation

被引：13
|
作者：
Diaz-Alvarez, Alba E. [1 ]
Mesas-Sanchez, Laura [1 ]
Diner, Peter [1 ]
机构：
[1] Uppsala Univ, Dept Chem BMC, SE-75123 Uppsala, Sweden
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 02期
关键词：
acylation; chiral resolution; kinetic resolution; secondary alcohols; ACYLATION; RACEMIZATION; AMINES; ACIDS; DMAP;
D O I：
10.1002/anie.201207648
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
"Ruth" helps iron! A novel method for the non-enzymatic dynamic kinetic resolution (DKR) of secondary aryl alcohols by the use of the planar chiral ferrocene derivative (+)-1 in combination with the ruthenium racemization catalyst 2 yields acetylated alcohols in high enantioselectivity and yield. This development opens opportunities for new developments in the field of non-enzymatic dynamic kinetic resolution. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：502 / 504
页数：3
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