A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19

被引：8

作者：

Chalkias, Athanasios ^{[1
]}

Barreto, Erin F. ^{[2
,3
]}

Laou, Eleni ^{[1
]}

Kolonia, Konstantina ^{[1
]}

Scheetz, Marc H. ^{[4
,5
,6
]}

Gourgoulianis, Konstantinos ^{[7
]}

Pantazopoulos, Ioannis ^{[8
]}

Xanthos, Theodoros ^{[9
]}

机构：

[1] Univ Thessaly, Fac Med, Sch Hlth Sci, Dept Anesthesiol, Larisa, Greece

[2] Mayo Clin, Dept Pharm, Rochester, MN USA

[3] Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deli, Rochester, MN USA

[4] Midwestern Univ, Dept Pharm Practice, Chicago Coll Pharm, Downers Grove, IL 60515 USA

[5] Midwestern Univ, Pharmacometr Ctr Excellence, Chicago Coll Pharm, Downers Grove, IL 60515 USA

[6] Midwestern Univ, Dept Pharmacol, Coll Grad Studies, Downers Grove, IL 60515 USA

[7] Univ Thessaly, Fac Med, Sch Hlth Sci, Dept Resp Med, Larisa, Greece

[8] Univ Thessaly, Fac Med, Sch Hlth Sci, Dept Emergency Med, Larisa, Greece

[9] European Univ Cyprus, Sch Med, Nicosia, Cyprus

来源：

CLINICAL THERAPEUTICS | 2021年 / 43卷 / 03期

基金：

美国国家卫生研究院;

关键词：

acute respiratory distress syndrome; anesthetics; COVID-19; inflammation; multiple organ dysfunction syndrome; SOLUBLE EPOXIDE HYDROLASE; SINGLE-DOSE ETOMIDATE; INTRAVENOUS ANESTHETICS; PROPOFOL; KETAMINE; MIDAZOLAM; EXPRESSION; MORTALITY; RESPONSES; SEPSIS;

D O I：

10.1016/j.clinthera.2021.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: The aim of the present article was to briefly summarize current knowledge about the immunomodulatory effects of general anesthetics and the possible clinical effects of this immunomodulation in patients with COVID-19. Methods: The PubMed, Scopus, and Google Scholar databases were comprehensively searched for relevant studies. Findings: The novel coronavirus causes a wide spectrum of clinical manifestations, with a large absolute number of patients experiencing severe pneumonia and rapid progression to acute respiratory distress syndrome and multiple organ failure. In these patients, the equilibrium of the inflammatory response is a major determinant of survival. The impact of anesthetics on immune-system modulation may vary and includes both proinflammatory and anti-inflammatory effects. (C) 2021 Elsevier Inc.

引用

页码：E57 / E70

页数：14

共 111 条

[1] THE WIDELY USED ANESTHETIC AGENT PROPOFOL CAN REPLACE ALPHA-TOCOPHEROL AS AN ANTIOXIDANT [J].

AARTS, L ;

VANDERHEE, R ;

DEKKER, I ;

DEJONG, J ;

LANGEMEIJER, H ;

BAST, A .

FEBS LETTERS, 1995, 357 (01) :83-85

[2] Opioids and immune modulation: more questions than answers [J].

Al-Hashimi, M. ;

Scott, S. W. M. ;

Thompson, J. P. ;

Lambert, D. G. .

BRITISH JOURNAL OF ANAESTHESIA, 2013, 111 (01) :80-88

[3]

Alhazzani W, 2020, INTENS CARE MED, V46, P854, DOI [10.1097/CCM.0000000000004363, 10.1007/s00134-020-06022-5]

[4] Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials [J].

Alhazzani, Waleed ;

Alshahrani, Mohamed ;

Jaeschke, Roman ;

Forel, Jean Marie ;

Papazian, Laurent ;

Sevransky, Jonathan ;

Meade, Maureen O. .

CRITICAL CARE, 2013, 17 (02)

[5] Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells [J].

Appelberg, Sofia ;

Gupta, Soham ;

Svensson Akusjarvi, Sara ;

Ambikan, Anoop T. ;

Mikaeloff, Flora ;

Saccon, Elisa ;

Vegvari, Akos ;

Benfeitas, Rui ;

Sperk, Maike ;

Stahlberg, Marie ;

Krishnan, Shuba ;

Singh, Kamal ;

Penninger, Josef M. ;

Mirazimi, Ali ;

Neogi, Ujjwal .

EMERGING MICROBES & INFECTIONS, 2020, 9 (01) :1748-1760

[6] Etomidate increases susceptibility to pneumonia in trauma patients [J].

Asehnoune, Karim ;

Mahe, Pierre Joachim ;

Seguin, Philippe ;

Jaber, Samir ;

Jung, Boris ;

Guitton, Christophe ;

Chatel-Josse, Nolwen ;

Subileau, Aurelie ;

Tellier, Anne Charlotte ;

Masson, Francoise ;

Renard, Benoit ;

Malledant, Yannick ;

Lejus, Corinne ;

Volteau, Christelle ;

Sebille, Veronique ;

Roquilly, Antoine .

INTENSIVE CARE MEDICINE, 2012, 38 (10) :1673-1682

[7] Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI [J].

Azam, Tariq U. ;

Shadid, Husam R. ;

Blakely, Pennelope ;

O'Hayer, Patrick ;

Berlin, Hanna ;

Pan, Michael ;

Zhao, Peiyao ;

Zhao, Lili ;

Pennathur, Subramaniam ;

Pop-Busui, Rodica ;

Altintas, Izzet ;

Tingleff, Jens ;

Stauning, Marius A. ;

Andersen, Ove ;

Adami, Maria-Evangelia ;

Solomonidi, Nicky ;

Tsilika, Maria ;

Tober-Lau, Pinkus ;

Arnaoutoglou, Eleni ;

Keitel, Verena ;

Tacke, Frank ;

Chalkias, Athanasios ;

Loosen, Sven H. ;

Giamarellos-Bourboulis, Evangelos J. ;

Eugen-Olsen, Jesper ;

Reiser, Jochen ;

Hayek, Salim S. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (11) :2725-2735

[8] Low-dose ketamine affects immune responses in humans during the early postoperative period [J].

Beilin, B. ;

Rusabrov, Y. ;

Shapira, Y. ;

Roytblat, L. ;

Greemberg, L. ;

Yardeni, I. Z. ;

Bessler, H. .

BRITISH JOURNAL OF ANAESTHESIA, 2007, 99 (04) :522-527

[9] Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells [J].

Bin Baek, Sang ;

Shin, Mal Soon ;

Han, Jin Hee ;

Moon, Sang Woong ;

Chang, Boksoon ;

Jeon, Jung Won ;

Yi, Jae Woo ;

Chung, Jun Young .

INTERNATIONAL NEUROUROLOGY JOURNAL, 2016, 20 (04) :296-303

[10] Persistent systemic inflammatory response syndrome is predictive of nosocomial infection in trauma [J].

Bochicchio, GV ;

Napolitano, LM ;

Joshi, M ;

Knorr, K ;

Tracy, JK ;

Ilahi, O ;

Scalea, TM .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2002, 53 (02) :245-251

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