Synthetic applications of 3,4-dihalo-2(5H)-furanones:: A formal total synthesis of nostoclides I and II

被引：24

作者：

Bellina, F ^{[1
]}

Rossi, R ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

SYNTHESIS-STUTTGART | 2002年 / 18期

关键词：

2(5H)-furanones; cross-coupling; regioselectivity; Stille reaction; benzylation;

D O I：

10.1055/s-2002-35994

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Benzyl-4-isopropyl-2(5H)-furanone, which is a precursor to two naturally-occurring cytotoxic (Z)-5-ylidene-2(5H)furanone derivatives, has been conveniently prepared from 3,4-dibromo-2(5H)-furanone by a three-step procedure involving two Pd-catalyzed cross-coupling reactions and a Rh(I)-catalyzed hydrogenation.

引用

页码：2729 / 2732

页数：4

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