Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis

被引：283
作者：
Horton, JD
机构：
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷
关键词：
cholesterol; fatty acids; lipogenesis; transcription factor;
D O I：
10.1042/bst0301091
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.
引用
收藏
页码：1091 / 1095
页数：5
相关论文
共 21 条
  • [1] Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
    Amemiya-Kudo, M
    Shimano, H
    Yoshikawa, T
    Yahagi, N
    Hasty, AH
    Okazaki, H
    Tamura, Y
    Shionoiri, F
    Iizuka, Y
    Ohashi, K
    Osuga, J
    Harada, K
    Gotoda, T
    Sato, R
    Kimura, S
    Ishibashi, S
    Yamada, N
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (40) : 31078 - 31085
  • [2] BROWN F, 1997, DEV BIOL STAND, V89, P1
  • [3] Regulation of gene expression by SREBP and SCAP
    Edwards, PA
    Tabor, D
    Kast, HR
    Venkateswaran, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1529 (1-3): : 103 - 113
  • [4] Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
    Foretz, M
    Guichard, C
    Ferré, P
    Foufelle, F
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) : 12737 - 12742
  • [5] Foretz M, 1999, MOL CELL BIOL, V19, P3760
  • [6] Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    Goldstein, JL
    Rawson, RB
    Brown, MS
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2002, 397 (02) : 139 - 148
  • [7] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    Horton, JD
    Goldstein, JL
    Brown, MS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) : 1125 - 1131
  • [8] Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
    Joseph, SB
    Laffitte, BA
    Patel, PH
    Watson, MA
    Matsukuma, KE
    Walczak, R
    Collins, JL
    Osborne, TF
    Tontonoz, P
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (13) : 11019 - 11025
  • [9] Mechanisms of nutritional and hormonal regulation of lipogenesis
    Kersten, S
    [J]. EMBO REPORTS, 2001, 2 (04) : 282 - 286
  • [10] Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    Liang, GS
    Yang, J
    Horton, JD
    Hammer, RE
    Goldstein, JL
    Brown, MS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) : 9520 - 9528
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