Inhibition of human immunodeficiency virus type 1 replication in primary CD4+ T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes

被引：16

作者：

Severino, ME

Sipsas, NV

Nguyen, PT

Kalams, SA

Walker, BD

Johnson, RP

Yang, OO

机构：

[1] Massachusetts Gen Hosp, AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Infect Dis Unit, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Southborough, MA 01772 USA

[4] New England Reg Primate Res Ctr, Southborough, MA 01772 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 14期

关键词：

D O I：

10.1128/JVI.74.14.6695-6699.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate that human immunodeficiency virus type I (HIV-1)-specific CD8(+) cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell dusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.

引用

收藏

页码：6695 / 6699

页数：5

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