Inhibition of human immunodeficiency virus type 1 replication in primary CD4+ T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes

被引：16
|
作者：
Severino, ME
Sipsas, NV
Nguyen, PT
Kalams, SA
Walker, BD
Johnson, RP
Yang, OO
机构：
[1] Massachusetts Gen Hosp, AIDS Res Ctr, Charlestown, MA 02129 USA
[2] Massachusetts Gen Hosp, Infect Dis Unit, Charlestown, MA 02129 USA
[3] Massachusetts Gen Hosp, Southborough, MA 01772 USA
[4] New England Reg Primate Res Ctr, Southborough, MA 01772 USA
来源：
JOURNAL OF VIROLOGY | 2000年 / 74卷 / 14期
关键词：
D O I：
10.1128/JVI.74.14.6695-6699.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We demonstrate that human immunodeficiency virus type I (HIV-1)-specific CD8(+) cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell dusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.
引用
收藏
页码：6695 / 6699
页数：5
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