Application of various optical and electrochemical aptasensors for detection of human prostate specific antigen: A review

被引：97

作者：

Ghorbani, Farzaneh ^{[1
,2
]}

Abbaszadeh, Hossein ^{[2
]}

Dolatabadi, Jafar Ezzati Nazhad ^{[3
]}

Aghebati-Maleki, Leili ^{[4
,5
]}

Yousefi, Mehdi ^{[3
,5
]}

机构：

[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Immunol Res Ctr, POB 6446-14155, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Med Sci, Dept Immunol, Tabriz, Iran

来源：

BIOSENSORS & BIOELECTRONICS | 2019年 / 142卷

关键词：

PSA; Aptamer; Biosensor; Aptasensor; Cancer biomarker; HYBRIDIZATION CHAIN-REACTION; GRAPHENE OXIDE APTASENSOR; SENSITIVE DETECTION; PHOTOELECTROCHEMICAL BIOSENSOR; ULTRASENSITIVE DETECTION; MICRORNA DETECTION; AU NANOPARTICLES; APTAMER SENSOR; HUMAN SERUM; FLUORESCENCE;

D O I：

10.1016/j.bios.2019.111484

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Early stage detection of prostate cancer, one of the main causes of mortality among men, is of great importance for better treatment of the patients. Prostate specific antigen (PSA) is a glycoprotein which has been considered as the most potential serological biomarker for the detection of prostate cancer. Among the various techniques employed for PSA detection, aptamer-based biosensors (aptasensors) have achieved notable attention because of their unique features and great potentials as diagnostic tools. A variety of strategies such as integration of nanomaterials (NMs) into the structure of aptasensors have also been applied for enhancing the sensitivity of PSA detection. This article reviews recent advances in various optical and electrochemical aptasensors used for PSA detection.

引用

页数：14

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