Can rheumatoid arthritis responsiveness to methotrexate and biologics be predicted?

被引：35

作者：

Bansard, Carine ^{[2
,3
]}

Lequerre, Thierry ^{[1
,2
,3
,4
]}

Daveau, Maryvonne ^{[2
,3
,4
]}

Boyer, Olivier ^{[2
,3
]}

Tron, Francois ^{[2
,3
,4
]}

Salier, Jean-Philippe ^{[2
,3
,4
]}

Vittecoq, Olivier ^{[1
,2
,3
,4
]}

Le-Loet, Xavier ^{[1
,2
,3
,4
]}

机构：

[1] Rouen Univ Hosp, Dept Rheumatol, F-76031 Rouen, France

[2] Univ Rouen, INSERM, U905, Fac Med Pharm, Rouen, France

[3] Univ Rouen, Inst Federatif Rech Multidisciplinaire Peptides 2, Inst Biomed Res, Fac Med Pharm, Rouen, France

[4] Consortium EGERIE, Rouen, France

来源：

RHEUMATOLOGY | 2009年 / 48卷 / 09期

关键词：

Rheumatoid arthritis; Methotrexate; Biologics; Biomarkers predictive of response; Pharmacogenetics; Pharmacogenomics; TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA GENE; SINGLE-NUCLEOTIDE POLYMORPHISMS; MESSENGER-RNA EXPRESSION; C-REACTIVE PROTEIN; CLINICAL-RESPONSE; INFLIXIMAB TREATMENT; THYMIDYLATE-SYNTHASE; MONOCLONAL-ANTIBODY; REDUCTASE GENES;

D O I：

10.1093/rheumatology/kep112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review briefly recapitulates the existing markers predictive of RA responsiveness to treatment, focusing on MTX alone or combined with a biologic. In addition to the demographic and clinical factors, an update is provided of the predictive biomarkers identified by large-scale gene and protein analyses that generated new insights into the ability of high-throughput analysis of biological systems to select new potential indicators. Among the large-scale analysis tools now available, pharmacogenetics and pharmacogenomics (including transcriptomic and proteomic approaches) have been shown to provide such new putative biomarkers of therapeutic responses.

引用

页码：1021 / 1028

页数：8

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