Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process

被引：15

作者：

Liu, Chenguang

Zeng, Zhixiong

Chen, Renzhi

Jiang, Xunjin

Wang, Yinglu

Zhang, Yandong ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 03期

关键词：

DIELS-ALDER REACTIONS; ASYMMETRIC TOTAL-SYNTHESIS; MUKAIYAMA ALDOL REACTION; HYBRID NATURAL-PRODUCTS; VARIABLE STRATEGY; FUSARISETIN; INHIBITOR; ACID; (-)-FUSARISETIN; CARBASUGARS;

D O I：

10.1021/acs.orglett.6b00036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, asymmetric total synthesis of (+)-fusarisetin A, a hybrid natural product, has been achieved. A one-pot four-reaction process efficiently delivered the tetracycle 2 which served as a key intermediate for the synthesis of the title natural product and its analogues through amino acid incorporation.

引用

页码：624 / 627

页数：4

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