The Epitranscriptome in Translation Regulation

被引：29
作者：
Peer, Eyal [1 ,2 ,3 ]
Moshitch-Moshkovitz, Sharon [1 ,2 ,3 ]
Rechavi, Gideon [1 ,2 ,3 ]
Dominissini, Dan [1 ,2 ,3 ]
机构：
[1] Tel Aviv Univ, Sackler Sch Med, IL-6997801 Tel Aviv, Israel
[2] Chaim Sheba Med Ctr, Canc Res Ctr, IL-5262160 Tel Hashomer, Israel
[3] Chaim Sheba Med Ctr, Wohl Ctr Translat Med, IL-5262160 Tel Hashomer, Israel
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2019年 / 11卷 / 08期
关键词：
MESSENGER-RNA METHYLATION; M(6)A RNA; YTH DOMAIN; ENHANCES TRANSLATION; STRUCTURAL BASIS; REVEALS; N-6-METHYLADENOSINE; RECOGNITION; PSEUDOURIDYLATION; ACTIVATION;
D O I：
10.1101/cshperspect.a032623
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output. mRNA modifications affect the translation machinery directly, by influencing translation initiation, elongation and termination, or by alteringmRNAlevels and subcellular localization. Features of modification-related translational control are described, charting a newand complex layer of translational regulation.
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页数：13
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