Rate of Change of Functional Abilities in Frontotemporal Dementia

被引：56
作者：
Mioshi, E. [1 ,4 ]
Hodges, J. R. [1 ,2 ,3 ]
机构：
[1] Prince Wales Med Res Inst, Sydney, NSW, Australia
[2] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
[3] Univ Cambridge, Dept Clin Neurosci, Cambridge, England
[4] MRC, Cognit & Brain Sci Unit, Cambridge, England
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 05期
关键词：
Frontotemporal dementia; Activities of daily living; Behavioural variant FTD; Semantic dementia; Progressive non-fluent aphasia; ALZHEIMERS-DISEASE; BEHAVIORAL VARIANT; DISABILITY ASSESSMENT; DECLINE; DEGENERATION; PROGRESSION; SEVERITY; MODERATE;
D O I：
10.1159/000255652
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: Frontotemporal dementia (FTD) causes progressive change in activities of daily living (ADLs) and little is known about their rate of decline. This study aimed to examine changes in ADLs, including subcomponents of initiation, planning or execution. Methods: A total of 72 ADL and general cognitive assessments were analysed. The patients were subdivided into behavioural variant FTD (bvFTD) pathological and phenocopy subgroups, semantic dementia (SemDem) and progressive non-fluent aphasia (PNFA). Results: Pathological bvFTD, SemDem and PNFA groups showed significant decline on ADLs after 12 months, while the phenocopy subgroup did not. In terms of subcomponents of ADLs, each variant showed different profiles of decline. The decline in ADL and cognitive scores were significantly correlated. Conclusions: FTD variants show differential annual rates of functional decline. The rate of decline should be taken into consideration when discussing prognosis. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：419 / 426
页数：8
相关论文
共 32 条
[1]   Focal cortical presentations of Alzheimer's disease [J].
Alladi, S. ;
Xuereb, J. ;
Bak, T. ;
Nestor, P. ;
Knibb, J. ;
Patterson, K. ;
Hodges, J. R. .
BRAIN, 2007, 130 :2636-2645
[2]   The effect of cholinesterase inhibitors on decline in multiple functional domains in Alzheimer's disease: a two-year observational study in the Sunnybrook dementia cohort [J].
Behl, Pearl ;
Lanctot, Krista L. ;
Streiner, David L. ;
Black, Sandra E. .
INTERNATIONAL PSYCHOGERIATRICS, 2008, 20 (06) :1141-1159
[3]   Differences between Pick disease and Alzheimer disease in clinical appearance and rate of cognitive decline [J].
Binetti, G ;
Locascio, JJ ;
Corkin, S ;
Vonsattel, JP ;
Growdon, JH .
ARCHIVES OF NEUROLOGY, 2000, 57 (02) :225-232
[4]   Progression in frontotemporal dementia - Identifying a benign Behavioral variant by magnetic resonance imaging [J].
Davies, Rhys R. ;
Kipps, Christopher M. ;
Mitchell, Joanna ;
Kril, Jillian J. ;
Halliday, Glenda M. ;
Hodges, John R. .
ARCHIVES OF NEUROLOGY, 2006, 63 (11) :1627-1631
[5]   Activities of daily living in patients with dementia - Clinical relevance, methods of assessment and effects of treatment [J].
Desai, AK ;
Grossberg, GT ;
Sheth, DN .
CNS DRUGS, 2004, 18 (13) :853-875
[6]   The Disability Assessment for Dementia scale:: A 12-month study of functional ability in mild to moderate severity Alzheimer disease [J].
Feldman, H ;
Sauter, A ;
Donald, A ;
Gélinas, I ;
Gauthier, S ;
Torfs, K ;
Parys, W ;
Mehnert, A .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2001, 15 (02) :89-95
[7]  
FOLSTEIN MF, 1975, J PSYCHIATR RES, V12, P198
[8]   Detailed assessment of activities of daily living in moderate to severe Alzheimer's disease [J].
Galasko, D ;
Schmitt, F ;
Thomas, R ;
Jin, S ;
Bennett, D ;
Ferris, S .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2005, 11 (04) :446-453
[9]   ASSESSMENT OF FUNCTIONAL-CHANGES IN ALZHEIMERS-DISEASE [J].
GAUTHIER, L ;
GAUTHIER, S .
NEUROEPIDEMIOLOGY, 1990, 9 (04) :183-188
[10]   Development of a functional measure for persons with Alzheimer's disease:: The disability assessment for dementia [J].
Gélinas, I ;
Gauthier, L ;
McIntyre, M ;
Gauthier, S .
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY, 1999, 53 (05) :471-481
1234