Highly efficient asymmetric hydrogenation of alkyl aryl ketones catalyzed by iridium complexes with chiral planar ferrocenyl phosphino-thioether ligands

被引：54

作者：

Le Roux, Erwan

Malacea, Raluca

Manoury, Eric

Poli, Rinaldo

Gonsalvi, Luca

Peruzzini, Maurizio

机构：

[1] CNR, ICCOM, I-50019 Sesto Fiorentino, Firenze, Italy

[2] CNRS, LCC, F-31077 Toulouse 4, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 03期

关键词：

alkyl aryl ketones; asymmetric catalysis; ferrocene ligands; hydrogenation; iridium; P; S ligands;

D O I：

10.1002/adsc.200600350

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Iridium complexes of planar-chiral ferrocenyl phosphine-thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ca. 250 h(-1). Furthermore, very high enantioselectivities (up to > 99 %) together with complete conversions were obtained for the asymmetric hydrogenation of various acetophenones at 10 degrees C.

引用

页码：309 / 313

页数：5

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