Nosocomial Spread of Colistin-Only-Sensitive Sequence Type 235 Pseudomonas aeruginosa Isolates Producing the Extended-Spectrum β-Lactamases GES-1 and GES-5 in Spain

被引：95

作者：

Viedma, Esther ^{[3
]}

Juan, Carlos ^{[2
]}

Acosta, Joshi ^{[3
]}

Zamorano, Laura ^{[2
]}

Otero, Joaquin R. ^{[3
]}

Sanz, Francisca ^{[3
]}

Chaves, Fernando ^{[3
]}

Oliver, Antonio ^{[1
,2
]}

机构：

[1] Hosp Son Dureta, Microbiol Serv, IUNICS, Palma de Mallorca 07014, Spain

[2] IUNICS, Microbiol Serv, Palma de Mallorca, Spain

[3] Hosp Univ 12 Octubre, Microbiol Serv, Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 11期

关键词：

RESISTANCE; MECHANISMS; INTEGRON; GENES; SUSCEPTIBILITY; IDENTIFICATION; EPIDEMIOLOGY; INFECTIONS; MUTATIONS; DIVERSITY;

D O I：

10.1128/AAC.00900-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mechanisms responsible for the increasing prevalence of colistin-only-sensitive (COS) Pseudomonas aeruginosa isolates in a Spanish hospital were investigated. Pulsed-field gel electrophoresis revealed that 24 (50%) of the studied isolates belonged to the same clone, identified as the internationally spread sequence type 235 (ST235) through multilocus sequence typing. In addition to several mutational resistance mechanisms, an integron containing seven resistance determinants was detected. Remarkably, the extended-spectrum beta-lactamase GES-1 and its Gly170Ser carbapenem-hydrolyzing derivative GES-5 were first documented to be encoded in a single integron. This work is the first to describe GES enzymes in Spain and adds them to the growing list of beta-lactamases of concern (PER, VIM, and OXA) detected in ST235 clone isolates.

引用

页码：4930 / 4933

页数：4

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