NAD+ in Brain Aging and Neurodegenerative Disorders

被引：525

作者：

Lautrup, Sofie ^{[1
,2
]}

Sinclair, David A. ^{[3
,4
]}

Mattson, Mark P. ^{[5
]}

Fang, Evandro F. ^{[1
,2
,6
]}

机构：

[1] Univ Oslo, Dept Clin Mol Biol, N-1478 Lorenskog, Norway

[2] Akershus Univ Hosp, N-1478 Lorenskog, Norway

[3] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA

[4] Univ New South Wales, Sch Med Sci, Dept Pharmacol, Sydney, NSW 2052, Australia

[5] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21205 USA

[6] Norwegian Ctr Hlth Ageing NO Age, Oslo, Norway

来源：

CELL METABOLISM | 2019年 / 30卷 / 04期

关键词：

NICOTINAMIDE ADENINE-DINUCLEOTIDE; PARKINSONS-DISEASE; MITOCHONDRIAL DYSFUNCTION; KYNURENINE PATHWAY; MOUSE MODEL; ALZHEIMERS-DISEASE; THERAPEUTIC APPROACH; SUBCELLULAR COMPARTMENTATION; EXTRACELLULAR-PRECURSORS; RESTORES COGNITION;

D O I：

10.1016/j.cmet.2019.09.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NAD(+) is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD(+)-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD(+) and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD(+)-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

引用

页码：630 / 655

页数：26

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